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US 7,923,566 B2Granted
Alternative process for the preparation of losartan
AssigneeSuven Life Sciences Limited
InventorsArava Veera Reddy, Siripalli Udaya Bhaskara Rao, Chinnapillai Rajendiran, Venkateswarlu Jasti
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Abstract
The invention relates to an improved process for the preparation of Losartan. The process comprising reacting 2-n-butyl-4-chloro-5-formyl imidazole with 2-(4-bromomethyl) benzonitrile in the presence of a phase transfer catalyst and an alkali, and reducing the resulting cyano aldehyde to produce a cyano alcohol which is further reacted with sodium azide in N-methyl pyrrolidinone and a salt to produce Losartan.
Claims18
A process for the preparation of Losartan having the formula:
- the process comprising:
- (i) reacting 2-n-butyl-4-chloro-5-formyl imidazole of the formula:
- with 4′-(Bromomethyl)-2-cyanobiphenyl of the formula:
- in the presence of a phase transfer catalyst to produce a cyano aldehyde of the formula
- (ii) reducing the formed cyano aldehyde with a reducing agent to produce a cyano alcohol of the formula
- (iii) treating the formed cyano alcohol with sodium azide and triethyl amine hydrochloride in a polar aprotic solvent to produce Losartan.
3 more elements
Dependencies are inferred from the claim text.