Quinolines

A compound of general formula (I),

• wherein
• X is selected from the group consisting of a bond, —NRa—, —O—, —S—, —SO2—, —NRb—S(O)2—, —NRc—CH2—, —OCH2—, —CH2O—, —SCH2—, —CH2S—, —NRd—, —C(O)—, —CH2—NRc—, —CH2CH2—, —CH═CH—, —CH2—S(O)2—, —OCH2CH2—, —SCH2CH2—, —NRcCH2CH2—, —CH2—NRd—C(O)—, —CH2—NRc—CH2—, —C(NRk)—, —C(O)—, —NRb—S(O)2—NRb—, and —C(N—ORp)—;
• R1 is mono- or bicyclic aryl, or mono- or bicyclic heteroaryl, each optionally substituted by one or more substituents independently selected from the group consisting of:
• halo,
• alkyl, optionally substituted by —OH or —CN,
• alkoxy,
• —S(O)2-alkyl,
• —NReRf,
• —S(O)2—NRgRh,
• haloalkyl,
• —CH2—O-alkyl,
• —(OCH2CH2)m—ORi, wherein m is an integer from 1 to 3,
• —(OCH2CH2)m—NRqRr, wherein m is an integer from 1 to 3,
• —CH2—(N-morpholino),
• —CH2—(OCH2CH2)m—ORj, wherein m is an integer from 1 to 3,
• hydroxy,
• cyano,
• nitro, and
• allyl;
• R2 is 5- to 7-membered cycloalkyl or heterocycloalkyl, or bicyclo[2.2.1]heptyl each optionally anellated with an aromatic 5- or 6-membered carbo- or heterocycle, each ring optionally and independently substituted with one or more substituents independently selected from the group consisting of:
• alkoxy,
• hydroxy,
• halo,
• alkyl, optionally substituted by —OH or —CN,
• —S(O)2-alkyl,
• —NReRf,
• —S(O)2—NRgRh,
• —CH2—O-alkyl,
• —(OCH2CH2)m—ORi, wherein m is an integer from 1 to 3,
• —CH2—(OCH2CH2)m—ORj, wherein m is an integer from 1 to 3,
• cyano,
• nitro, and
• allyl;
• Ra, Rb, Rc, Rd, Re, Rf, Rg, Rh, Ri, Rj, Rk, Rp, Rq and Rr are each independently selected from the group consisting of:
• hydrogen, alkyl and —(CH2)n-cycloalkyl, wherein n is an integer from 0 to 3;
• or a pharmaceutically-acceptable-acid addition salt thereof.