Method for obtaining pure tetrahydrocannabinol
AssigneeCilag AG
InventorsEnver Arslantas, Ulrich Weigl
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Abstract
The invention relates to a method for obtaining pure tetrahydrocannabinol from reaction mixtures containing tetrahydrocannabinol compounds or from raw products containing tetrahydrocannabinol compounds. According to said method, the tetrahydrocannabinol compounds in the reaction mixture or in the raw product are converted into crystallisable derivatives, preferably using a suitable solvent, said derivatives are then crystallised and isolated, and the pure tetrahydrocannabinol compounds are then obtained from the crystallised derivatives. The invention also related to the use of compounds produced in this way for the production of a medicament for human therapy, and to the medicaments thus produced.
Claims17
Process for obtaining pure tetrahydrocannabinol from reaction mixtures containing tetrahydrocannabinol compounds or from crude product containing tetrahydrocannabinol compounds, characterized in that the tetrahydrocannabinol compound in the reaction mixture or in the crude product is converted to a crystallizable derivative of formulae (III) and (IIIA):
- in which
- R1 is hydrogen, chlorine or (C1-10)-alkyl;
- X is —O— (oxygen) or —NH—;
- and
- R2 is an optionally substituted aliphatic or aromatic radical which optionally carries a substituent capable of salt formation;
- or a heterocyclic radical which optionally is itself capable of salt formation and/or optionally carries a substituent capable of salt formation;
- or a radical of an aliphatic or aromatic polybasic acid;
- whereby said derivative is crystallized out and isolated and the pure tetrahydrocannabinol compound is then obtained from the crystallized derivative.
Dependencies are inferred from the claim text.