Phenyl-substituted pyrimidine compounds useful as kinase inhibitors

A compound of formula (I)

• or a pharmaceutically acceptable salt thereof, an enantiomer thereof or a diastereomer thereof, wherein:
• two of X1, X2, and X3 are N, and the remaining one of X1, X2, and X3 is —CR1;
• R1 is hydrogen;
• n is zero, 1, 2, or 3;
• each R2 is independently C1-C8 alkyl, substituted C1-C8 alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, —OR4, —SR4, —CO2R4, —C(═O)NR4R5, —NR4R5, —S(═O)R6, —SO2R6, —SO2NR4R5, —NR4SO2NR5R6, —NR4SO2R6, —NR4C(═O)R5, —NR4CO2R5, —NR4C(═O)NR5R6, halogen, cyano, aryl, substituted aryl, heterocyclo, and/or substituted heterocyclo;
• each R4 is independently hydrogen, C1-C8 alkyl, substituted C1-C8 alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heterocyclo, and/or substituted heterocyclo;
• each R5 is independently hydrogen, C1-C8 alkyl, substituted C1-C8 alkyl, cycloalkyl, and/or substituted cycloalkyl;
• wherein when R4 and R5 are alkyl and/or substituted alkyl and are bonded to the same atom, R4 and R5 can be optionally linked together to form a four-, five-, or six-membered ring heterocyclo or substituted heterocyclo;
• each R6 is independently C1-8 alkyl, substituted C1-C8 alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heterocyclo, and/or substituted heterocyclo;
• wherein when R5 and R6 are alkyl and/or substituted alkyl and are bonded to the same atom, R5 and R6 can be optionally linked together to form a four-, five-, or six-membered ring heterocyclo or substituted heterocyclo;
• Z is hydrogen, C1-C8 alkyl, C1-C8 substituted alkyl, cycloalkyl, substituted cycloalkyl, —OR7, —SR7, —CO2R7, —C(═O)NR7R8, —NR7R8, —S(═O)R9, —SO2R8, —SO2NR7R8, —NR7SO2NR8R9, —NR7SO2R9, —NR7C(═O)R8, —NR7CO2R8, —NR7C(═O)NR8R9, halogen, cyano, aryl, substituted aryl, heterocyclo, or substituted heterocyclo;
• R7 is hydrogen, C1-C8 alkyl, substituted C1-C8 alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heterocyclo, or substituted heterocyclo;
• R8 is hydrogen, C1-C8 alkyl, substituted C1-C8 alkyl, cycloalkyl, or substituted cycloalkyl;
• wherein when R7 and R8 are alkyl and/or substituted alkyl and are bonded to the same atom, R7 and R8 can be optionally linked together to form a four-, five-, or six-membered ring heterocyclo or substituted heterocyclo;
• R9 is C1-C8 alkyl, substituted C1-C8 alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heterocyclo, or substituted heterocyclo;
• and
• wherein when R8 and R9 are alkyl and are bonded to the same atom, R8 and R9 can be optionally linked together to form a four-, five-, or six-membered ring heterocyclo or substituted heterocyclo;
• with the provisos that:
• (a) R2 is not optionally substituted phenoxy attached to para-position of the phenyl ring;
• (b) R7 is not pyrazolyl, substituted pyrazolyl, alkyl substituted triazolyl, indazolyl, or substituted indazolyl when Z is —NR7R8;
• and
• (c) n is 1, 2, or 3 when Z is unsubstituted phenyl.