Isolated tumor rejection antigen precursor proteins MAGE-2 and MAGE-3
AssigneeLudwig Institute for Cancer Research
InventorsThierry Boon, Pierre Van Der Bruggen, Benoit Van Den Eynde, Aline Van Pel, Etienne De Plaen, Christophe Lurquin, Patrick Chomez, Catia Traversari
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Abstract
The invention relates to an isolated DNA sequence which codes for an antigen expressed by tumor cells which is recognized by cytotoxic T cells, leading to lysis of the tumor which expresses it. Also described are cells transfected by the DNA sequence, and various therapeutic and diagnostic uses arising out of the properties of the DNA and the antigen for which it codes.
Claims3
The isolated MAGE tumor rejection antigen precursor protein, wherein said protein is encoded by a nucleic acid molecule, the complementary sequence of which hybridizes to SEQ ID NO:
- 8 at 0.1×SSC, 0.1% SDS, wherein said tumor rejection antigen precursor is obtainable from melanoma cells and has an amino acid sequence encoded by a nucleotide sequence set forth in SEQ ID NO:
- 9, or 11.
Dependencies are inferred from the claim text.