Methods for diagnosing celiac sprue and reagents useful therein
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsFelix Hausch, Gary Gray, Lu Shan, Chaitan Khosla
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Abstract
Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
Claims5
A purified oligopeptide selected from the group consisting of a C-terminal amidated counterpart oligopeptide of SEQ ID NO:12;
- a counterpart oligopeptide of SEQ ID NO:12 conjugated to a label;
- or a conjugate of tissue transglutaminase and SEQ ID NO:12 or a deamidated counterpart oligopeptide of SEQ ID NO:12.
A purified deamidated counterpart oligopeptide of SEQ ID NO:12, wherein said deamidated counterpart oligopeptide consists of the amino acid sequence set forth in SEQ ID NO:12, wherein the oligopeptide is deamidated at one or more glutamine residues.
A purified counterpart oligopeptide of SEQ ID NO:12 conjugated to a label, wherein said label is a fluorescent label.
A purified counterpart oligopeptide of SEQ ID NO:12 conjugated to a label, wherein said label is a 13C label.
Dependencies are inferred from the claim text.