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US 7,923,471 B2Granted
Method of treating dry eye disorders and uveitis
AssigneeAlcon Inc.
InventorsPeter G. Klimko, Mark R. Hellberg, Daniel A. Gamache
Life of this patent
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Abstract
The topical use of 5,6,7-trihydroxyheptanoic acid and analogs are disclosed for the treatment of dry eye disorders and uveitis.
Claims9
A method for the treatment of dry eye or uveitis in a mammal, which comprises topically administering to the eye of the mammal a composition comprising a pharmaceutically acceptable carrier and a pharmaceutically effective amount of a compound of formula I:
- wherein
- R1 is C2H5, CO2R, or a carboxylate salt of formula CO2−R+;
- R+ is Li+, Na+, K+, or NH4+;
- R is H, CH3, C2H5, n-C3H7, or i-C3H7;
- and
- R7, R8, R9 are H;
- or R7 and R8 or R8 and R9 together constitute a carbonyl group (C═O), thus forming a cyclic carbonate;
- or OR8R1 together form a lactone.
5 more elements
Dependencies are inferred from the claim text.