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US 7,923,468 B2Granted
1,4-benzothiepin-1,1-dioxide derivatives which are substituted with cyclohexyl groups, method for producing the same, drugs containing said compounds and use thereof
AssigneeSanofi-Aventis Deutschland GmbH
InventorsWendelin Frick, Heiner Glombik, Stefan Theis, Hubert Heuer, Hans-Ludwig Schaefer, Werner Kramer
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Abstract
This invention relates to Novel 1,4-benzothiepin-1,1-dioxide derivatives which are substituted with cyclohexyl groups, method for producing the same, drugs containing said compounds and use thereof.
Claims17
A compound of the formula I
- wherein
- X is CH2, O or NH;
- R1 is (C1-C4)alkyl;
- R2, R2′, R3, R3′, R4, R4′, R5, R5′, R6, R6′ are, independently of one another, H, OH, F, Cl, Br, I, CF3, NO2, N3, CN, COOH, COO(C1-C6)alkyl, CONH2, CONH(C1-C6)alkyl, CON[(C1-C6)alkyl]2, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, O—(C1-C6)alkyl, where one, more than one, or all hydrogen(s) in the alkyl radicals may be replaced by fluorine;
- C(═NH)(NH2), PO3H2, SF5, SO3H, OSO3H, SO2—NH2, SO2NH(C1-C6)alkyl, SO2N[(C1-C6)alkyl]2, S—(C1-C6)alkyl, S—(CH2)n-phenyl, SO—(C1-C6)alkyl, SO—(CH2)n-phenyl, SO2—(C1-C6)alkyl, SO2—(CH2)n-phenyl, where n may be 0-6, and the phenyl radical may be substituted up to twice by F, Cl, Br, OH, CF3, NO2, CN, OCF3, O—(C1-C6)alkyl, (C1-C6)alkyl or NH2;
- NH2, NH—(C1-C6)alkyl, N((C1-C6)alkyl)2, NH(C1-C7)acyl, phenyl, O—(CH2)n-phenyl, where n may be 0-6, where the phenyl ring may be substituted one to 3 times by F, Cl, Br, I, OH, CF3, NO2, CN, OCF3, O—(C1-C6)alkyl, (C1-C6)alkyl, NH2, NH(C1-C6)alkyl, N((C1-C6)alkyl)2, SO2—CH3, COOH, COO—(C1-C6)alkyl, CONH2;
- or a pharmaceutically acceptable salt thereof.
4 more elements
Dependencies are inferred from the claim text.