3-substituted-5- and 6-aminoalkyl indole-2-carboxylic acid amides and related analogs as inhibitors of casein kinase I

A method for the treatment of a patient suffering from a disease or disorder ameliorated by the inhibition of casein kinase Iε activity wherein said disease or disorder is selected from the group consisting of mood disorders and sleep disorders, comprising the administration of a compound of formula I or formula II, an enantiomer, or a pharmaceutically acceptable salt thereof, optionally in combination with one or more pharmaceutically acceptable carriers, diluents or excipients,

• wherein
• X is S or S(O)n;
• R1 is H or C1-C6alkyl;
• R2 is NR5R6;
• R3 is aryl or heterocycle;
• R4 is C1-C6alkyl or halogen;
• R5 is H or C1-C6alkyl;
• R6 is H or C1-C6alkyl;
• R7 is CH2NR8R9 wherein
• R8 is H, C1-C10alkyl, C3-C8cycloalkyl, aryl, aryl(C1-C6alkyl), aryl(C2-C6alkenyl), diaryl(C2-C6alkenyl), heterocycle, heterocycle(C1-C6alkyl), heterocycle(C2-C6alkenyl), hydroxy(C1-C6alkyl), dihydroxy(C2-C6alkyl), acyl, C1-C6alkoxycarbonyl, aryl(C1-C6alkoxy)carbonyl, carbamoyl(C1-C6 alkyl), or P;
• R9 is H, C1-C10alkyl, heterocycle(C1-C6alkyl) or heterocycle(C2-C6alkenyl);
• or
• R8 and R9 together with the nitrogen to which they are attached form a heterocycle;
• and wherein P is Gly, or L- or D-Ala, Val, Leu, Ile, Ser, Cys, Thr, Met, Pro, Phe, Tyr, Trp, His, Lys, Arg, Asp, Gly, Asn or Gln;
• m is 0, 1 or 2;
• and
• n is 1 or 2.