Cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation

A compound selected from:

• N(7)-Piperidino-5-(2-bromophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-Benzyl-5-(2-bromophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-Morpholino-5-(4-chlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(3-Pyridylmethyl)-5-(4-chlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(4-Pyridylmethyl)-5-(4-chlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-Cyclohexyl-5-(4-chloroyhenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(N-cyclohexyl-N-methylamino)-5-(4-chlorophenyl)-5,6-diazatetracyclo [7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-Cyclohexylmethyl-5-(4-chlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(Adamantan-1-yl)-5-(4-chlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8)-6-diene-7-carboxamide,
• N(7)-(1S,2endo-1,3,3-Trimethyl-bicyclo[2.2.1]hept-2-yl)-5-(4-chlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8)-6-diene-7-carboxamide,
• N(7)-(2-Chlorobenzyl)-5-(4-chlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(4-Chlorobenzyl)-5-(4-chlorophenyl)-5,6-diazatetracyclo [7.3.1.13,11.04,8]tetradeca-4(8)-6-diene-7-carboxamide,
• N(7)-(4-Fluorobenzyl)-5-(4-chlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8)-6-diene-7-carboxamide,
• N(7)-(2,4-Difluorobenzyl)-5-(4-chlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(2,6-Difluorobenzyl)-5-(4-chlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(4-Trifluoromethylbenzyl)-5-(4-chlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-((S)-1-Phenylethyl))-5-(4-chlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-((R)-1-Phenylethyl))-5-(4-chlorophenyl)-5,6-diazatetracyclo[7.3.1.1 3,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(1-Methyl-1-phenylethyl))-5-(4-chlorophenyl)-5,6-diazatetracyclo [7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(2-Pyridylmethyl)-5-(4-chlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(N′-phenylamino)-5-(4-chlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(N′-phenylamino)-5-(4-chlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide hydrochloride,
• N(7)-(2-Chlorophenylamino)-5-(4-chlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(2-Chlorophenylamino)-5-(4-chlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide, hydrochloride,
• N(7)-[(4-chlorophenyl)amino)]-5-(4-chlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(2,4-Dichlorophenylamino)-5-(4-chlorophenyl)-5,6-diazatetracyclo [7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide.
• N(7)-[(2,4-Dichlorophenyl-N′-methylamino]-5-(4-chlorophenyl)-5,6-diazatetracyclo [7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-[(2,4-Dichlorophenyl-N′-methylamino]-5-(4-chlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide hydrochloride,
• N(7)-(2,4-Dichlorophenyl-N′-cyclohexylamino)-5-(4-chlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(4-Fluorophenylamino)-5-(4-chlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(4-Fluorophenylamino)-5-(4-chlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide hydrochloride,
• N(7)-(2,4-Difluorophenylamino]-5-(4-chlorophenyl)-5,6-diazatetracyclo [7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(3-fluorophenylamino)-5-(4-chlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(3-Chloro-2-pyridylamino)-5-(4-chlorophenyl)-5,6-diazatetracyclo [7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(5-Chloro-2-pyridylamino)-5-(4-chlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(2-Phenylethyl)-5-(4-chlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8)-6-diene-7-carboxamide,
• N(7)-(N′,N′-Diphenylamino)-5-(4-chlorophenyl)-5,6-diazatetracyclo[7.3.1.1 3,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N7-[1-(2-Chlorophenyl)ethyl]-5-(4-chlorophenyl)-5,6-diazatetracyclo [7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-Benzyl-5-(4′-chlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8)-6-diene-7-carboxamide,
• N(7)-Piperidino-5-(4′-chlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8)-6-diene-7-carboxamide,
• 7-(4′-Chlorophenyl)-6,7-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8)-5-dien-5-yl-piperidinomethanone,
• N(7)-Phenyl-5-(4′-chlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8)-6-diene-7-carboxamide,
• N(7)-Piperidino-5-(2,4-difluorophenyl)-5,6-diazatetracyclo [7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(Adamantan-1-yl)-5-(2,4-difluorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8)-6-diene-7-carboxamide,
• N(7)-(1S,2endo-1,3,3-Trimethyl-bicyclo[2.2.1]hept-2-yl)-5-(2,4-difluorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8)-6-diene-7-carboxamide,
• N(7)-(S-1-phenylethyl))-5-(2,4-difluorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(R-1-phenylethyl)-5-(2,4-difluorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(1-Methyl-1-phenylethyl)-5-(2,4-difluorophenyl)-5,6-diazatetracyclo [7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(2-Chlorobenzyl)-5-(2,4-difluorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(2,4-Dichlorophenylamino)-5-(2,4-difluorophenyl)-5,6-diazatetracyclo [7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-[1-(2-Chlorophenyl)ethyl]-5-(2,4-difluorophenyl)-5,6-diazatetracyclo [7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-[(S)-1-Phenylpropyl]-5-(2,4-difluorophenyl)-5,6-diazatetracyclo [7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N7-[1-(2-Chlorophenyl)-1-methylethyl]-5-(2,4-difluorophenyl)-5,6-diazatetracyclo[7.3.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• Methyl(2R)-2-[7-(2,4-difluorophenyl)-6,7-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),5-dien-5-ylcarboxamido]-2-phenylethanoate,
• Methyl(2S)-2-[7-(2,4-difluorophenyl)-6,7-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),5-dien-5-ylcarboxamido]-2-phenylethanoate,
• N7-(3-Hydroxyadamantan-1-yl)-5-(2,4-difluorophenyl)-5,6-diazatetracyclo [7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(1-Methyl-1-phenylethyl]-5-(4-fluorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(Adamantan-1-yl)-5-(2,4-difluorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8)-6-diene-7-carboxamide,
• N7-(Adamantan-2-yl)-5-(4-fluorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N7-(1,3,3-Trimethyl bicyclo[2.2.1]hept-2-yl)-5-(4-fluorophenyl)-5,6-diazatetracyclo [7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-Piperidino-5-(4-methylphenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(2,4-Dichlorophenylamino)-5-(4-methylphenyl)-5,6-diazatetracyclo [7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(2-Chlorobenzyl)-5-(4-methylphenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-Piperidino-5-(4-methoxyphenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N7-(2-Chlorobenzyl)-5-(4-methoxyphenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(2,4-Dichlorophenylamino)-5-(4-methoxyphenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-Piperidino-5-[(2-chlorophenyl)phenyl]-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-[(2,4-Dichlorophenyl)amino]-5-phenyl-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-phenyl-5-phenyl-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8)-6-diene-7-carboxamide;
• N(7)-piperidino-5-phenyl-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8)-6-diene-7-carboxamide,
• N(7)-Benzyl-5-phenyl-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8)-6-diene-7-carboxamide;
• 7-phenyl-6,7-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8)-5-dien-5-yl-piperidinomethanone;
• N(7)-(4-Fluorobenzyl)-5-(2,4-dichlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-Phenylamino-5-(2,4-dichlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8), 6-diene-7-carboxamide,
• N(7)-(2-Chlorophenylamino)-5-(2,4-dichlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(2,4-Dichlorophenylamino)-5-(2,4-dichlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(2-Bromophenylamino)-5-(2,4-dichlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(N′,N′-Diphenylamino)-5-(2,4-dichlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(2-Phenylethyl)-5-(2,4-dichlorophenyl)-5,6-diazatetracyclo[7. 3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-Benzyl-5-(2′,4′-dichlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8)-6-diene-7-carboxamide,
• N(7)-piperidino-5-(2′,4′-dichlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-(2,4-Dichlorophenylamino)-5-(2-chlorophenyl)-5,6-diazatetracyclo [7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-Benzyl-5-(2′-chlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8)-6-diene-7-carboxamide,
• N(7)-cyclohexyl-5-(2′-chlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8)-6-diene-7-carboxamide,
• N(7)-piperidino-5-(2′-chlorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8)-6-diene-7-carboxamide,
• N7-(2-Chlorobenzyl)-5-(5-chloro-2-pyridyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-Benzyl-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8)-6-diene-7-carboxamide,
• N(7)-piperidino-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8)-6-diene-7-carboxamide,
• 6,7-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8)-5-dien-5-yl-piperidinomethanone;
• N(7)-piperidino-6-methyl-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8)-6-diene-7-carboxamide,
• N(7)-piperidino-5-methyl-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8)-6-diene-7-carboxamide,
• N(7)-(1-methyl-1-phenylethyl)-6-pentyl-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4,7-diene-7-carboxamide,
• N(7)-(1-methyl-1-phenylethyl)-5-pentyl-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8)-6-diene-7-carboxamide,
• N(7)-[(1R)-2-Hydroxy-1-phenylethyl]-5-(2,4-difluorophenyl)-5,6-diazatetracyclo [7.3.1.13,11.048]tetradeca-4(8),6-diene-7-carboxamide,
• N(7)-[(1S)-2-Hydroxy-1-phenylethyl]-5-(2,4-difluorophenyl)-5,6-diazatetracyclo [7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• and pharmaceutically acceptable salts thereof.

A compound selected from:

• N(3)-Piperidino-1-phenyl-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-Cyclohexyl-1-phenyl-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-Benzyl-1-phenyl-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-Phenylamino-1-phenyl-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-Piperidino-1-(2-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-Cyclohexyl-1-(2-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-Benzyl-1-(2-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-Phenylamino-1-(2-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-Piperidino-1-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• 1-(4-Chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazol-3-yl piperidino methanone,
• N(3)-Cyclohexyl-1-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-Cyclopentyl-1-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-[(N-Cyclohexyl-N-methyl)amino]-1-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-Phenyl-1-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(3-Chlorophenyl)-1-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(4-Chlorophenyl)-1-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(3-Bromophenyl)-1-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(2-Methoxyphenyl)-1-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(4-tert-Butylphenyl)-1-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-Benzyl-1-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(2-Chlorobenzyl)-1-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(4-Chlorobenzyl)-1-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(2,4-Dichlorobenzyl)-1-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(2-Bromobenzyl)-1-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(4-Bromobenzyl)-1-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(4-Fluorobenzyl)-1-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(4-Trifluoromethylbenzyl)-1-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-Phenylamino-1-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-[(4-Chlorophenyl)amino]-1-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-[(2,4-Dichlorophenyl)amino]-1-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-[(3,4-Dichlorophenyl)amino]-1-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-[(2-Fluorophenyl)amino]-1-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-[(3-Fluorophenyl)amino]-1-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-[(4-Fluorophenyl)amino]-1-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-[(2,4-Difluorophenyl)amino]-1-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(N′,N′-Diphenylamino-1-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-Cyclohexyl-1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-Cyclohexylmethyl-1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(N,N-Dicyclohexylamino)-1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(4H-1,2,4-triazol-4-yl)-1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(1,3,3-Trimethyl bicyclo[2.2.1]hept-2-yl)-1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(Adamantan-1yl)-1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-Phenyl-1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(2,4-Difluorophenyl)-1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(2-Fluorobenzyl)-1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(4-Fluorobenzyl)-1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(2,4-Difluorobenzyl)-1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(2,6-Difluorobenzyl)-1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(2-Chlorobenzyl)-1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(4-Chlorobenzyl)-1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(2,4-Dichlorobenzyl)-1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-[S-(1-phenylethyl)]-1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-[R-(1-phenylethyl)]-1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(2-phenylethyl)-1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-[2-(4-fluorophenyl)ethyl]-1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-Phenylamino-1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-[(2-Chlorophenyl)amino]-1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-[N-(2-Chlorophenyl)-N-methylamino]-1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-[(4-Chlorophenyl)amino]-1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-[(2,4-Dichlorophenyl)amino]-1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-[(2,4-dichlorophenyl)-N-methylamino]-1-(2,4-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-[(3,4-Dichlorophenyl)amino]-1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-[(2-Bromophenyl)amino]-1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-[(2-Fluorophenyl)amino]-1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-[(2,4-Difluorophenyl)amino]-1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-[(3-Fluorophenyl)amino]-1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-[(3-chloropyridin-2-yl)amino]-1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(5)-piperidino-3-(2′,4′-dichlorophenyl)-3,4-diazatricyclo[5.2.1.02,6]deca-2(6),4-diene-5-carboxamide,
• N(5)-benzyl-3-(2′,4′-dichlorophenyl)-3,4-diazatricyclo[5.2.1.02,6]deca-2(6),4-diene-5-carboxamide,
• N(3)-Piperidino-1-(2-bromophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-Cyclohexyl-1-(2-bromophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-Benzyl-1-(2-bromophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-Phenylamino-1-(2-bromophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-Piperidino-1-(4-bromophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-Cyclohexyl-1-(4-bromophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-Benzyl-1-(4-bromophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-Phenylamino-1-(4-bromophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-[(2-Fluorophenyl)amino]-1-(4-bromophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-Cyclohexyl-1-(4-fluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-Benzyl-1-(4-fluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N5-(Adamantan-2-yl)-3-(4-fluorophenyl)-3,4-diazatricyclo[5.2.1.02,6]deca-2(6),4-diene-5-carboxamide,
• N5-(1-Methyl-1-phenylethyl)-3-(4-fluorophenyl)-3,4-diazatricyclo[5.2.1.02,6]deca-2(6),4-diene-5-carboxamide,
• N5-(Adamantan-1-yl)-3-(4-fluorophenyl)-3,4-diazatricyclo[5.2.1.02,6]deca-2(6),4-diene-5-carboxamide,
• N(3)-Phenylamino-1-(4-fluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-Phenylamino-1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-[(2-Chlorophenyl)amino]-1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-[(2-bromophenyl)amino]-1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-[(2-Fluorophenyl)amino]-1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-Piperidino-1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-Cyclohexyl-1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(Cyclohexylmethyl)-1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-[S-(1-Phenylethyl)]-1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(R-1-phenylethyl)-1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(1-Methyl-1-phenylethyl)-1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N5-[1-(2-Chlorophenyl)-1-methylethyl]-3-(2,4-difluorophenyl)-3,4-diazatricyclo [5.2.1.02.6]deca-2(6),4-diene-5-carboxamide,
• N(3)-(1,3,3-Trimethylbicyclo[2.2.1]hept-2-yl)-1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N5-(2-Chlorobenzyl)-3-(2,4-difluorophenyl)-3,4-diazatricyclo[5.2.1.02,6]deca-2(6),4-diene-5-carboxamide,
• N5-(4-Chlorobenzyl)-3-(2,4-difluorophenyl)-3,4-diazatricyclo[5.2.1.02,6]deca-2(6),4-diene-5-carboxamide,
• N5-(1-Ethyl-1-phenylpropyl)-3-(2,4-difluorophenyl)-3,4-diazatricyclo[5.2.1.02,6]deca-2(6),4-diene-5-carboxamide,
• N5-[(1S)-1-Phenylpropyl]-3-(2,4-difluorophenyl)-3,4-diazatricyclo[5.2.1.02,6]deca-2(6),4-diene-5-carboxamide,
• Methyl(2S)-2-[5-(2,4-difluorophenyl)-4,5-diazatricyclo[5.2.1.02,6]deca-2(6),3-dien-3-ylcarboxamido]-2-phenylethanoate,
• N5-[(1S)-2-Hydroxy-1-phenylethyl]-3-(2,4-difluorophenyl)-3,4-diazatricyclo [5.2.1.02,6]deca-2(6),4-diene-5-carboxamide,
• N(3)-(tert-Butyl)-1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• (4R,7S)-N(3)-(tert-Butyl)-1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• (4S,7R)—N(3)-(tert-Butyl)-1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N5-n-Pentyl-3-(2,4-difluorophenyl)-3,4-diazatricyclo[5.2.1.02,6]deca-2(6),4-diene-5-carboxamide,
• N5-(2,4-Dichlorobenzyl)-3-(2,4-difluorophenyl)-3,4-diazatricyclo[5.2.1.02,6]deca-2(6),4-diene-5-carboxamide,
• N5-(1-phenylcyclopropyl)-3-(2,4-difluorophenyl)-3,4-diazatricyclo[5.2.1.02,6]deca-2(6),4-diene-5-carboxamide,
• N5-(2-Adamantyl)-3-(2,4-difluorophenyl)-3,4-diazatricyclo[5.2.1.02,6]deca-2(6),4-diene-5-carboxamide,
• N5-(2-Methyl-2-adamantyl)-3-(2,4-difluorophenyl)-3,4-diazatricyclo[5.2.1.02,6]deca-2(6),4-diene-5-carboxamide,
• N7-(3-Hydroxyadamantan-1-yl)-5-(2,4-difluorophenyl)-5,6-diazatetracyclo [7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxamide,
• 4-[5-(2,4-Difluorophenyl)-4,5-diazatricyclo[5.2.1.02,6]deca-2(6), 3-dien-3-ylcarboxamido]morpholine,
• N(3)-(tert-Pentyl)-1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-Cyclopropanmethyl-1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-Cyclobutyl-1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(Tetrahydro-2H-4-pyranmethyl)-1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-Cyclopropyl-1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(4-methylpiperazino)-1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• Methyl (2R)-2-[5-(2,4-difluorophenyl)-4,5-diazatricyclo[5.2.1.02,6]deca-2(6),3-dien-3-ylcarboxamido]-2-phenylethanoate,
• N(3)-[(1R)-2-Hydroxy-1-phenylethyl]-1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(tert-Butyl)-1-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(Tetrahydro-2-furanylmethyl)-1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(tert-Butyl)-1-(4-fluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(tert-Butyl)-1-(4-bromophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(tert-Butyl)-1-(3,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• Methyl(2S)-2-[5-(2,4-difluorophenyl)-4,5-diazatricyclo[5.2.1.02,6]deca-2(6),3-dien-3-ylcarboxamido]-2-(4-fluorophenyl)ethanoate,
• N(3)-(tert-Butyl)-1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(4-Hydroxyphenyl)-1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(tert-Butyl)-1-(2-ethoxy,4-fluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(2-furylmethyl)-1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(2-thiophenemethyl)-1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-[(1S)-2-Hydroxy-1-(4-fluorophenyl)ethyl]-1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• Methyl-(2S)-2-[5-(2,4-difluorophenyl)-4,5-diazatricyclo[5.2.1.02,6]deca-2(6), 3-dien-3-ylcarboxamido]-4-methylpentanoate,
• N(3)-(Adamantan-1-yl)-1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(tert-butyl)-1-(4-fluorobenzyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(tert-butyl)-2-(4-fluorobenzyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(tert-butyl)-1-(4-methylbenzyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(2-hydroxyethyl)-1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(Thienylethyl)-1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(Isopropyl)-1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-[(1S)-2-Methoxy-1-phenylethyl]-1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(tert-butyl)-2-(4-methylbenzyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• and pharmaceutically acceptable salts thereof.

A compound selected from:

• N(3)-Phenyl-1-(2,4-dichlorophenyl)-7,8,8-trimethyl-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-[(2-Fluorophenyl)amino]-1-(2,4-Dichlorophenyl)-7,8,8-trimethyl-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-[(2,4-Difluorophenyl)amino]-1-(2,4-Dichlorophenyl)-7,8,8-trimethyl-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-[(3-chloropyridin-2-yl)amino]-1-(2,4-Dichlorophenyl)-7,8,8-trimethyl-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(Adamantan-1-yl)-1-(2,4-difluorophenyl)-7,8,8-trimethyl-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(1,3,3-Trimethylbicyclo[2.2.1]hept-2-yl)-1-(2,4-difluorophenyl)-7,8,8-trimethyl-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-(1-Methyl-1-phenylethyl))-1-(2,4-difluorophenyl)-7,8,8-trimethyl-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• (4R,7S)—N(3)-tert-Butyl-1-(2,4-difluorophenyl)-7,8,8-trimethyl-4,5,6,7-tetrahydro-1H-methano-indazole-3-carboxamide,
• Methyl (2R)-2-[1-(2,4-difluorophenyl)-7,8,8-trimethyl-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamido]-2-phenylethanoate,
• N(3)-[(1R)-2-Hydroxy-1-phenylethyl]-1-(2,4-difluorophenyl)-7,8,8-trimethyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxamide,
• N(3)-pentyl-1-(2,4-difluorophenyl)-7,8,8-trimethyl-4,5,6,7-tetrahydro-1H-methano-indazole-3-carboxamide,
• (4S,7R)—N(3)-tert-Butyl-1-(2,4-difluorophenyl)-7,8,8-trimethyl-4,5,6,7-tetrahydro-1H-methano-indazole-3-carboxamide,
• and pharmaceutically acceptable salts thereof.

A compound selected from:

• N(12)-Benzyl-10-(2,4-dichlorophenyl)-10,11-diazatetracyclo[6.5.2.02,7.09,13]pentadeca-2,4,6,9(13),11-pentaene-12-carboxamide,
• N(12)-Piperidino-10-(2,4-dichlorophenyl)-10,11-diazatetracyclo[6.5.2.02,7.09,13]pentadeca-2,4,6,9(13),11-pentaene-12-carboxamide,
• N(12)-Piperidino-10-(2,4-dichlorophenyl)-10,11-diazatetracyclo [6.5.2.02,7.09,13]pentadeca-2,4,6,9(13),11-pentaene-12-carboxamide, hydrochloride.
• N(12)-[(N′-Cyclohexyl-N′-methyl)amino]-10-(2,4-dichlorophenyl)-10,11-diazatetracyclo[6.5.2.02,7.09,13]pentadeca-2,4,6,9(13),11-pentaene-12-carboxamide,
• N(12)-{N′-[(2,4-Dichlorophenyl)-N′-methyl]amino}-10-(2,4-dichlorophenyl)-10,11-diazatetracyclo[6.5.2.02,7.09,13]pentadeca-2,4,6,9(13),11-pentaene-12-carboxamide,
• N(12)-(Adamantan-1-yl)-10-(2,4-dichlorophenyl)-10,11-diazatetracyclo [6.5.2.02,7.09,13]pentadeca-2,4,6,9(13),11-pentaene-12-carboxamide,
• N12-(1,3,3-Trimethylbicyclo[2.2.1]hept-2-yl)-10-(2,4-dichlorophenyl)-10,11-diazatetracyclo[6.5.2.02,7.09,13]pentadeca-2(7),3,5,9(13),11-pentaene-12-carboxamide,
• N12-(1-Methyl-1-phenylethyl)-10-(2,4,dichlorophenyl)-10,11-diazatetracyclo [6.5.2.02,7.09,13]pentadeca-2,4,6,9(13),11-pentaene-12-carboxamide,
• N12-(1-Methyl-1-phenylethyl)-10-(2,4-difluorophenyl)-10,11-diazatetracyclo [6.5.2.02,7.09,13]pentadeca-2,4,6,9(13),11-pentaene-12-carboxamide,
• and pharmaceutically acceptable salts thereof.

A compound selected from:

• N(12)-Benzyl-10-(2,4-difluorophenyl)-10,11-diazatetracyclo[6.5.1.02,7.09,13]tetradeca-2,4,6,9(13),11-pentaene-12-carboxamide,
• N(12)-(1-Methyl-1-phenylethyl)-10-(2,4-difluorophenyl)-10,11-diazatetracyclo [6.5.1.02,7.09,13]tetradeca-2,4,6,9(13),11-pentaene-12-carboxamide,
• N(12)-tert-Butyl-10(2,4-difluorophenyl)-10,11-diazatetracyclo [6.5.1.02,7.09,13]tetradeca-2,4,6,9(13),11-pentaene-12-carboxamide,
• and pharmaceutically acceptable salts thereof.

A compound selected from:

• 5-(2-bromophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxylic acid,
• 5-(4-chlorophenyl)-5,6-diazatetracyclo[7,3,1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxylic acid,
• 5-(2,4-Difluorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxylic acid,
• 5-(4-Fluorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxylic acid,
• 5-(4-methylphenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxylic acid,
• 5-(4-Methoxyphenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxylic acid,
• 5-phenyl-5,6-diazatetracyclo[7,3,1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxylic acid,
• 5-(2,4-dichlorophenyl)-5,6-diazatetracyclo[7,3,1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxylic acid,
• 5-(2-chlorophenyl)-5,6-diazatetracyclo[7,3,1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxylic acid,
• 5-(5-chloropyridyl)-5,6-diazatetracyclo[7,3,1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxylic acid,
• 5,6-diazatetracyclo[7,3,1.13,11,04,8]tetradeca-4(8),6-diene-7-carboxylic acid,
• 6-Pentyl-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4,7-diene-7-carboxylic acid,
• 5-Pentyl-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8)-6-diene-7-carboxylic acid,
• 1-Phenyl-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxylic acid,
• 1-(2-Chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxylic acid,
• 1-(4-Chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxylic acid,
• 1-(2,4-Dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxylic acid,
• 1-(2-Bromophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxylic acid,
• 1-(4-Bromophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxylic acid,
• 1-(4-Fluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxylic acid,
• 1-(2,4-Difluorophenyl)-4, 5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxylic acid,
• (R or S) 1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxylic acid,
• (S or R) 1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxylic acid,
• 1-(2,4-Dichlorophenyl)-7,8,8-trimethyl-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxylic acid,
• 3-(2,4-difluorophenyl)-1,10,10-trimethyl-3,4-diazatricyclo[5.2.1.02,6]deca-2(6),4-diene-5-carboxylic acid,
• 10-(2,4-dichlorophenyl)-10,11-diazatetracyclo[6.5.2.02,7.09,13]pentadeca-2,4,6,9(13),11-pentaene-12-carboxylic acid,
• 10-(2,4-difluorophenyl)-10,11-diazatetracyclo[6.5.2.02,7.09,13]pentadeca-2,4,6,9(13),11-pentaene-12-carboxylic acid,
• 13Endo,14endo-16-(4-chlorophenyl)-15,17-dioxo-10-(2,4-dichlorophenyl)-10,11,16-triazapentacyclo[6.5.5.02,7.09.13.014,18]octadeca-2,4,6,9(13),11-pentaene-12-carboxylic acid,
• 10-(2,4-Difluorophenyl)-10,11-diazatetracyclo[6. 5.1.02,7.09,13]tetradeca-2,4,6,9(13),11-pentaene-12-carboxylic acid,
• 3-(2,4-difluorophenyl)-3,4-diazatricyclo[5.2.2.02,6]undeca-2(6),4-diene-5-carboxylic acid,
• 3-(3,4-dichlorophenyl)-3,4-diazatricyclo[5.2.1.02,6]deca-2(6),4-diene-5-carboxylic acid,
• 3-(2-ethoxy-4-fluorophenyl)-3,4-diazatricyclo[5.2.1.02,6]deca-2(6),4-diene-5-carboxylic acid.
• 2-(4-Methylbenzyl)-4,5,6,7-tetrahydro-2H-4,7-methano-indazole-3-carboxylic acid,
• 3-(4-methylbenzyl)-3,4-diazatricyclo[5.2.1.02,6]deca-2(6),4-diene-5-carboxylic acid,
• 2-(4-Fluorobenzyl)-4,5,6,7-tetrahydro-2H-4,7-methano-indazole-3-carboxylic acid,
• 1-(4-Fluorobenzyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxylic acid,
• and pharmaceutically acceptable salts thereof.

A compound selected from:

• Ethyl 5-(2-bromophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxylate,
• Ethyl 5-(4-chlorophenyl)-5,6-diazatetracyclo[7,3,1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxylate,
• Ethyl 5-(2,4-Difluorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxylate,
• Ethyl 5-(4-Fluorophenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxylate,
• Ethyl 5-(4-methylphenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxylate,
• Ethyl 5-(4-Methoxyphenyl)-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxylate,
• Ethyl 5-phenyl-5,6-diazatetracyclo[7,3,1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxylate,
• Ethyl 5-(2,4-dichlorophenyl)-5,6-diazatetracyclo[7,3,1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxylate,
• Ethyl 5-(2-chorophenyl)-5,6-diazatetracyclo[7,3,1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxylate,
• Ethyl 5-(5-chloropyridyl)-5,6-diazatetracyclo[7,3,1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxylate,
• Ethyl 5,6-diazatetracyclo[7,3,1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxylate,
• Ethyl 6-methyl-5,6-diazatetracyclo[7,3,1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxylate,
• Ethyl 5-methyl-5,6-diazatetracyclo [7,3,1.13,11.04,8]tetradeca-4(8),6-diene-7-carboxylate,
• Ethyl 6-pentyl-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4,7-diene-7-carboxylate,
• Ethyl 5-pentyl-5,6-diazatetracyclo[7.3.1.13,11.04,8]tetradeca-4(8)-6-diene-7-carboxylate,
• Ethyl 1-phenyl-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxylate,
• Ethyl 1-(2-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxylate,
• Ethyl 1-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxylate,
• Ethyl 1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxylate,
• Ethyl 1-(2-bromophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxylate,
• Ethyl 1-(4-bromophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxylate,
• Ethyl 1-(4-fluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxylate,
• Ethyl 1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxylate,
• Ethyl 1-(2,4-dichlorophenyl)-7,8,8-trimethyl-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxylate,
• Ethyl 3-(2,4-difluorophenyl)-1,10,10-trimethyl-3,4-diazatricyclo[5.2.1.02,6]deca-2(6),4-diene-5-carboxylate,
• Ethyl 10-(2,4-dichlorophenyl)-10,11-diazatetracyclo[6.5.2.02,7.09,13]pentadeca-2,4,6,9(13),11-pentaene-12-carboxylate,
• Ethyl 10-(2,4-difluorophenyl)-10,11-diazatetracyclo[6.5.2.02,7.09,13]pentadeca-2,4,6,9(13),11-pentaene-12-carboxylate,
• Ethyl 13endo, 14endo-16-(4-chlorophenyl)-15,17-dioxo-10-(2,4-dichlorophenyl)-10,11,16-triazapentacyclo[6.5.5.02,7.09,13.014,18]octadeca-2,4,6,9(13),11-pentaene-12-carboxylate,
• Ethyl 10-(2,4-difluorophenyl)-10,11-diazatetracyclo[6.5.1.02,7.09,13]tetradeca-2,4,6,9(13),11-pentaene-12-carboxylate,
• Ethyl-3-(2,4-difluorophenyl)-3,4-diazatricyclo[5.2.2.02,6]undeca-2(6),4-diene-5-carboxylate,
• Ethyl 3-(3,4-dichlorophenyl)-3,4-diazatricyclo[5.2.1.02,6]deca-2(6),4-diene-5-carboxylate,
• Ethyl 3-(2-ethoxy-4-fluorophenyl)-3,4-diazatricyclo[5.2.1.02,6]deca-2(6),4-diene-5-carboxylate,
• Ethyl 4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxylate,
• Ethyl 2-(4-methylbenzyl)-4,5,6,7-tetrahydro-2H-4,7-methano-indazole-3-carboxylate,
• Ethyl 1-(4-methylbenzyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxylate,
• Ethyl 2-(4-fluorobenzyl)-4,5,6,7-tetrahydro-2H-4,7-methano-indazole-3-carboxylate,
• Ethyl 1-(4-fluorobenzyl)-4,5,6,7-tetrahydro-1H-4,7-methano-indazole-3-carboxylate,
• and pharmaceutically acceptable salts thereof.

A compound selected from:

• Ethyl 2-oxo-(5-oxotricyclo[4.3.1.13,8]undec-4-yl)acetate,
• Ethyl 2-oxo-2(3-oxobicyclo[2.2.1]hept-2-yl)acetate,
• Ethyl 2-(3-hydroxy-4,7,7-trimethyl bicyclo[2.2.1]hept-2-en-2-yl-2-oxoacetate,
• Ethyl 2-oxo-2-(10-oxotricyclo[6.2.2.02,7]dodeca-2,4,6-trien-9-yl)acetate,
• Ethyl 9endo,13endo-2-[11-(4-chlorophenyl)-10,12,15-trioxo-11-azatetracyclo [6.5.2.02,7.09,13]pentadeca-2,4,6-trien-14-yl]-2-oxoacetate,
• Ethyl 2-oxo-2-(10-oxotricyclo[6.2.1.02,7]undeca-2(7),3,5-trien-9-yl)acetate,
• Ethyl 2-hydroxy-2-(3-oxabicyclo[2.2.2]octa-2-yliden)acetate,
• 9-Endo,13-endo-11-(4-chlorophenyl)-11-azatetracyclo[6.5.2.02,7.09,13]pentadeca-2,4,6-triene-10,12,14-trione,
• and pharmaceutically acceptable salts thereof.

A selective CB2 agonist having the formula:

• wherein
• each occurrence of R is independently substituted or unsubstituted alkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl;
• R1 is hydrogen;
• R2 is substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heterocyclic group, substituted or unsubstituted heteroaryl group, substituted or unsubstituted heteroarylalkyl, or NR3R4;
• or R1 and R2 may be joined together to form an unsubstituted piperidinyl;
• R3 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl or substituted or unsubstituted cycloalkyl and R4 is substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl or substituted or unsubstituted cycloalkyl;
• or R3 and R4, when bound to a common atom, may be joined together to form an optionally substituted 3 to 7 membered saturated or unsaturated cyclic ring, which may optionally include at least two heteroatoms selected from O, NR3 or S.

A compound of the formula (Ib):

• an analog thereof, a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable ester thereof, a stereoisomer thereof,
• wherein
• R is 2-chlorophenyl, 4-chlorophenyl, 2,4-dichlorophenyl, 2-bromophenyl, 4-bromophenyl, 4-fluorophenyl, 2,4-difluorophenyl, 4-methylphenyl, 4-methoxyphenyl, or 2-(4-chlorophenyl)phenyl;
• R1 is hydrogen;
• and
• R2 is t-butyl, n-pentyl, cyclopentyl, cyclohexyl, adamantan-1-yl, 2-methyladamantan-2-yl, 3-hydroxyadamantan-1-yl, 1,3,3-trimethylbicyclo[2.2.1]hept-2-yl, 1-phenylcyclopropyl, cyclohexylmethyl, phenyl, 3-chlorophenyl, 4-chlorophenyl, 3-bromophenyl, 2-methoxyphenyl, 4-tert-butylphenyl, 2,4-difluorophenyl, benzyl, 2-chlorobenzyl, 4-chlorobenzyl, 2,4-dichlorobenzyl, 2-fluorobenzyl, 4-fluorobenzyl, 2,4-difluorobenzyl, 2,6-difluorobenzyl, 2-bromobenzyl, 4-bromobenzyl, 4-trifluoromethylbenzyl, 1-phenylethyl, 1-methyl-1-phenylethyl, 2-phenylethyl, 1-(2-chlorophenyl)ethyl, 2-(4-fluorophenyl)ethyl, 1-phenylpropyl, 1-ethyl-1-phenylpropyl, 1-(2-chlorophenyl)-1-methylethyl, methylphenylethanoate, 2-hydroxy-1-phenylethyl, piperidinyl, morpholinyl, pyridinyl, 1,2,4-triazol-4-yl, 2-pyridylmethyl, 3-pyridylmethyl, or 4-pyridylmethyl.