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US 7,923,464 B2Granted
Benzimidazole derivatives and their use for modulating the GABAA receptor complex
AssigneeNeuroSearch A/S
InventorsJanus S. Larsen, Lene Teuber, Philip K. Ahring, Elsebet Østergaard Nielsen, Naheed Mirza
Life of this patent
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Abstract
This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
Claims8
A compound selected from the group consisting of 3′-[5-((R)-1-Amino-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile;
- an N-oxide of 3′-[5-((R)-1-amino-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile;
- and a pharmaceutically acceptable salt of 3′-[5-((R)-1-amino-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile.
A pharmaceutical composition comprising
- (a) 3′-[5-((R)-1-amino-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile, an N-oxide of 3′-[5-((R)-1-amino-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile, or a pharmaceutically acceptable salt of 3′-[5-((R)-1-amino-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile;
- and
- (b) at least one of a pharmaceutically acceptable carrier, a pharmaceutically acceptable excipient and a pharmaceutically acceptable diluent.
Dependencies are inferred from the claim text.