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US 7,923,459 B2Granted
Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-N-propyl-piperidine
AssigneeNsab, Filial Af Neurosearch Sweden AB, Sverige
InventorsDonald R. Gauthier, Richard Desmond, Paul N. Devine
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Abstract
The present invention is directed to processes for the preparation of 4-(3-methanesulfonyl-phenyl)-1-N-propylpiperidine (I) or a pharmaceutically acceptable salt thereof, which comprises: oxidizing a sulfide of the formula (II): with a catalytic oxidizing agent and an oxidant; to give a compound of the formula (III): followed by catalytic reduction of the compound of formula (III).
Claims15
A process for preparing a compound of the formula I:
- or a pharmaceutically acceptable salt thereof,
- which comprises:
- oxidizing a sulfide of the formula II:
- with a catalytic oxidizing agent and an oxidant;
- to give a compound of the formula III:
- followed by catalytic reduction of the compound of the formula III;
- to give the compound of the formula I:
- or a pharmaceutically acceptable salt thereof.
5 more elements
Dependencies are inferred from the claim text.