Methods of converting a patient's treatment regimen from intravenous administration of an opioid to oral co-administration of morphine and oxycodone using a dosing algorithm to provide analgesia

A method of converting a treatment for pain consisting essentially of intravenous administration of morphine to a treatment for pain consisting essentially of oral co-administration of immediate release morphine sulfate and oxycodone hydrochloride in a weight ratio of about 3:2, in a human patient in need of analgesia, the method comprising:

• determining a four-hour average oral morphine equivalent dose of morphine administered intravenously to the human patient;
• and
• orally co-administering to the human patient a first dose of an immediate release dosage form of morphine sulfate and oxycodone hydrochloride, wherein:
• (i) if the four-hour average oral morphine equivalent dose is between about 0 mg and about 30 mg, then the first dose is no greater than about 12 mg of morphine sulfate and about 8 mg of oxycodone hydrochloride;
• (ii) if the four-hour average oral morphine equivalent dose is greater than about 30 mg and less than or equal to about 40 mg, then the first dose is about 18 mg of morphine sulfate and about 12 mg of oxycodone hydrochloride;
• (iii) if the four-hour average oral morphine equivalent dose is greater than about 40 mg and less than or equal to about 120 mg, then the first dose is about 24 mg of morphine sulfate and about 16 mg of oxycodone hydrochloride.

A method of converting a treatment for pain consisting essentially of intravenous administration of morphine to a treatment for pain consisting essentially of oral co-administration of immediate release morphine sulfate and oxycodone hydrochloride in a weight ratio of about 3:2, in a human patient in need of analgesia, the method comprising:

• determining a four-hour average oral morphine equivalent dose of morphine administered intravenously to the human patient;
• and
• orally co-administering to the human patient a first dose of an immediate release dosage form of morphine sulfate and oxycodone hydrochloride, wherein:
• (i) if the four-hour average oral morphine equivalent dose is between about 0 mg and about 30 mg, then the first dose is about 12 mg of morphine sulfate and about 8 mg of oxycodone hydrochloride;
• (ii) if the four-hour average oral morphine equivalent dose is greater than about 30 mg and less than or equal to about 40 mg, then the first dose is about 18 mg of morphine sulfate and about 12 mg of oxycodone hydrochloride;
• (iii) if the four-hour average oral morphine equivalent dose is greater than about 40 mg and less than or equal to about 120 mg, then the first dose is about 24 mg of morphine sulfate and about 16 mg of oxycodone hydrochloride.