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US 7,923,447 B2Granted
Parenteral solutions containing metolazone
AssigneeAcademic Pharmaceuticals, Inc.
InventorsJohn C. Somberg, Vasant V. Ranade
Life of this patent
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Abstract
Disclosed herein are parenteral solutions containing 7-halo-1,2,3,4-tetrahydro-3-aryl-6-quinazoline sulfonamide in N,N-dimethylactamide, polyethylene glycol and D5W useful in the treatment of hypertension, heart failure and renal disease leading to edematous states. Also disclosed are methods for preparing such solutions.
Claims17
A solution suitable for parenteral administration, comprising:
- 1 to 15 mg/mL metolazone dissolved in up to 2% by volume N,N-dimethylacetamide (DMAC) and the reminder of the solution being 5% dextrose (D5W), wherein the pH of the solution is from 6.8-8.
A method of treating hypertension, comprising:
- parenterally administering a therapeutically effective amount of a solution, comprising:
- 1 to 15 mg/mL metolazone dissolved in up to 2% by volume N,N-dimethylacetamide (DMAC) and the reminder of the solution being 5% dextrose (D5W), wherein the pH of the solution is from 6.8-8.
Dependencies are inferred from the claim text.