Back to results
US 7,923,444 B2Granted
Alkyl substituted homopiperazine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
AssigneeNeuroSearch A/S
InventorsDan Peters, Bjarne H. Dahl, Gunnar M. Olsen, Elsebet Oestergaard Nielsen, Jørgen Scheel-Kruger, John Paul Redrobe
Life of this patent
Estimating the term…
Abstract
This invention relates to novel alkyl substituted homopiperazine derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
Claims12
A homopiperazine compound of Formula I:
- any of its stereoisomers or any mixture of its stereoisomers,
- or a pharmaceutically acceptable salt thereof,
- wherein
- Ra represents hydrogen or alkyl;
- which alkyl is optionally substituted with one or more substituents independently selected from the group consisting of:
- halo, trifluoromethyl, trifluoromethoxy, cyano, hydroxy, amino, nitro, alkoxy, cycloalkoxy, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl and alkynyl;
- Rb represents an aryl or a heteroaryl group,
- which aryl or heteroaryl group is optionally substituted with one or more substituents independently selected from the group consisting of:
- halo, trifluoromethyl, trifluoromethoxy, cyano, hydroxy, amino, nitro, alkoxy, cycloalkoxy, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl and alkynyl;
- each of R3, R3′, R5 and R5′ represents alkyl;
- and
- each of R2, R2′, R6, R6′, R7 and R7′ represents hydrogen.
9 more elements
Dependencies are inferred from the claim text.