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AssigneeDong Wha Pharmaceutical Co., Ltd.
InventorsJei Man Ryu, Jin Soo Lee, Sae Kwang Ku, Jung Woo Lee, Hee Bog Yang
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Disclosed herein is a composition for the treatment bone fracture comprising N-hydroxy-4-{5-[4-( 5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxyl-benzamidine, 4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl) phenoxy]pentoxy}-benzamidine or pharmaceutically acceptable salts thereof as a medicinally effective ingredient. The composition of the present invention can significantly reduce the volume of bony callus, and increase bony density and strength of bony callus, and decrease the contents of connective tissue and cartilage tissue in bony callus, and thus promote loss and ossification of the bony callus formed during the fracture healing process. Therefore, the composition of the present invention is useful for the treatment of bone fracture.
A method of treating bone fracture, the method comprising:
A method of increasing the number of osteoclasts in a bony callus of a fractured bone of a patient during the early stage of recovery from a bone fracture, the method comprising administering to the patient at the early stage of recovery from a bone fracture a benzamidine compound represented by the following chemical formula 1 or its pharmaceutically acceptable salt:
Dependencies are inferred from the claim text.