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US 7,923,438 B2Granted
Use of cyclipostin derivatives for the treatment of mycobacterial infectious diseases
AssigneeSanofi-Aventis
InventorsGerhard Seibert, Luigi Toti, Joachim Wink
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Abstract
The invention relates to the use of a compound of the formula (I) for the treatment of bacterial infections caused by mycobacteria, nocardia or corynebacteria, wherein E is phosphorus; X1, X2 and X3 are oxygen; and R1 and R2 are as defined in the specification.
Claims5
A method for the treatment of a bacterial infection caused by mycobacteria, nocardia or corynebacteria, the method comprising administering an effective amount of a compound of the formula (I)
- wherein
- R1 is
- 1. a saturated carbon chain having 10 to 18 carbon atoms, which can be straight-chain or branched, and in which the carbon chain is optionally mono- or disubstituted by a radical selected from
- 1.1 OH,
- 1.2 ═O,
- 1.3 O—(C1-C6)alkyl, in which alkyl is linear or branched,
- 1.4 O—(C2-C6)alkenyl, in which alkenyl is linear or branched,
- 1.5 (C1-C6)alkyl, in which alkyl is linear or branched,
- 1.6 aryl,
- 1.7 (C1-C6)alkylene-benzene,
- 1.8 diphenyl,
- 1.9 NH—(C1-C6)alkyl, in which alkyl is linear or branched,
- 1.10 NH—(C2-C6)alkenyl, in which alkenyl is linear or branched,
- 1.11 NH2,
- 1.12 ═S,
- 1.13 S—(C1-C6)alkyl, in which alkyl is linear or branched
- R2 is
- (C1-C6)alkyl, wherein alkyl is unsubstituted, or mono- or disubstituted by a radical as described in 1.1-1.3;
- in any stereochemical form, or a mixture of any stereochemical forms in any ratio, or a physiologically tolerable salt thereof.
16 more elements
Dependencies are inferred from the claim text.