Methods and compounds for controlled release of recombinant parvovirus vectors
AssigneeUniversity of North Carolina - Chapel Hill
InventorsPaul E. Monahan, Richard Jude Samulski, Joseph E. Rabinowitz
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Abstract
The invention uses recombinant parvoviruses, and particularly recombinant adeno-associated virus (rAAV) to deliver genes and DNA sequences for gene therapy following manipulation of the therapeutic virus for packaging and transport. The invention delivers therapeutic viral vectors via rAAV affixed to support matrixes (i.e., sutures, surgically implantable materials, grafts, and the like).
Claims27
A surgically implantable matrix comprising a recombinant adeno-associated virus (rAAV) vector dried thereto, wherein the rAAV vector comprises a heterologous nucleic acid.
A method of storing an adeno-associated virus (AAV) vector, the method comprising drying the AAV vector to a surgically implantable matrix.
Dependencies are inferred from the claim text.