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AssigneeAbbott Point of Care Inc.
InventorsCindra A. Widrig Opalsky, David Opalsky, Andrzej MacZuszenko, Imants R. Lauks, Rhonda J. Cheadle
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This invention is a disposable cartridge for use at the patient side to perform traditional coagulation assays on fresh whole blood or blood derivative samples. The cartridge, in use with an electronic analyzer allows a fluid sample to be metered and quantitatively mixed with reagents which activate the coagulation cascade. An artificial substrate for thrombin, the enzyme whose action results in clot formation is also provided. Clot formation is subsequently detected using a microfabricated sensor also housed within the cartridge which detects electrochemically the product of the thrombin reaction upon the synthetic substrate.
A method of determining a coagulation parameter in a sample using a single-use cartridge in combination with an analyzer, wherein the cartridge includes an entry port for receiving a sample, an entry port closure, a holding chamber in communication at a first end with the entry port, and a capillary stop in communication with the holding chamber at a second end, wherein the capillary stop is in communication with an analysis chamber containing a reagent, a conductimetric sensor sensitive to the displacement of a fluid sample across the conductimetric sensor and an amperometric sensor, wherein the holding chamber is in communication with an overflow chamber for receiving and retaining excess sample, wherein the overflow chamber is in communication with a pneumatic pump actuated by the analyzer, wherein the analyzer is capable of actuating the pneumatic pump to displace the sample from the holding chamber, the method comprising the steps of:
Dependencies are inferred from the claim text.