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US 7,923,237 B2Granted
Method and apparatus for combined electrochemical synthesis and detection of analytes
AssigneeIntel Corporation
InventorsHernan Adolfo Castro, Gordon Holt, Brandon Barnett, Handong Li, Narayan Sundararajan, Wei Wang
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Abstract
Described are devices and methods for detecting binding on an electrode surface. In addition, devices and methods for electrochemically synthesizing polymers and devices and methods for synthesizing and detecting binding to the polymer on a common integrated device surface are described.
Claims20
A device comprising:
- a substrate;
- at least one drive electrode, at least one sensing electrode and at least one reference electrode on a surface of the substrate;
- and an integrating charge amplifier connected to the at least one sensing electrode and configured to detect a change in charge or effective capacitance on a surface of the sensing electrode due to binding of an analyte to the sensing electrode, wherein the sensing electrode comprises a sensing routing path, the reference electrode comprises a reference routing path and the sensing routing path and reference routing path are matched and wherein the reference electrode configured to provide differential measurements of change in charge and effective capacitance.
A device comprising:
- a substrate;
- at least one drive electrode and at least one reference electrode on a surface of the substrate, wherein the at least one drive electrode is connected to both drive circuitry configured to drive a polymer synthesis and an integrating charge amplifier, wherein a surface area of the drive electrode is larger than a surface area of the reference electrode.
A device comprising:
- a substrate;
- an electrode on a surface of the substrate;
- a drive circuitry connected to the electrode and configured to apply a voltage to the surface of the electrode to drive a polymer synthesis;
- and an integrating charge amplifier connected to the electrode configured to detect an analyte, wherein a surface area of a drive electrode is larger than a surface area of a reference electrode.
1 more element
Dependencies are inferred from the claim text.