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US 7,923,041 B2Granted
Compositions and methods for enhancing cognitive function
AssigneesSignum Biosciences, Inc., The Trustees of Princeton University
InventorsJeffry Stock, Maxwell Stock, Haoming Gu, Zhu Li, Peter Wolanin
Life of this patent
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Abstract
Disclosed are compositions for promoting general health and well-being, comprising an extract of a botanical raw material, wherein said extract inhibits the carboxyl demethylating activity of a protein phosphatase, and methods of making and using same.
Claims9
A method to obtain a botanical extract having PP2A methylation modifying activity, the method comprising steps of:
- contacting botanical raw material selected from the group consisting of coffea, gingko, garlic, bacopa, butcher's broom, flaxseed oil, ginseng, grape seed, St. John's wort, artichoke powder, tea leaf, tobacco, and cocoa, with a polar solvent to form an extract solution;
- and
- separating the extract solution into a plurality of fractions;
- assessing PP2A carboxyl methylation modifying activity in at least two fractions, so that those fractions containing PP2A carboxyl methylation modifying activity are identified;
- and
- obtaining as a botanical extract at least one fraction or combination of fractions that
- (1) is essentially free of caffeine, caffeic acid, and chlorogenic acid;
- and
- (2) contains the carboxyl methylation modifying activity at a concentration sufficient so that, when the extract is contacted with protein phosphatase 2A (“PP2A”) and an enzyme selected from the group consisting of PP2A-specific protein methyltransferase (“PPMT”), PP2A-specific protein methylesterase (“PPME”), and combination thereof, the extent of PP2A carboxyl methylation is altered as compared with that observed absent the extract.
6 more elements
Dependencies are inferred from the claim text.