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US 7,923,037 B2Granted
Liquid chalcogenide compositions and methods of manufacturing and using the same
AssigneeIkaria, Inc.
InventorsKevin J. Tomaselli, Paul A. Hill, Thomas L. Deckwerth, Edward Wintner, Csaba Szabo
Life of this patent
Estimating the term…
Abstract
The present invention provides novel stable, liquid compositions comprising chalcogenides or salts thereof. These compositions may be used for a variety of purposes, including the treatment and prevention of ischemic or hypoxic injury, as well as in the preservation of biological matter.
Claims8
A sterile, stable aqueous pharmaceutical composition comprising:
- a solution of deoxygenated water and sodium sulfide nonahydrate,
- wherein the sodium sulfide nonahydrate produces Na2S, H2S and HS−,
- wherein the concentration of H2S is in the range of 1.0 mg/mL to 4.0 mg/mL;
- wherein the solution is adjusted to a pH in the range of 7.5 to 8.5 by adding HCI to the solution;
- wherein the solution has an osmolarity in the range of 250-330 mOsmol/L;
- wherein the solution further comprises sulfide oxidation products selected from the group consisting of polysulfide, sulfite, sulfate and thiosulfate;
- wherein the oxidation products comprise sulfate in the range of (0%-1.0%), sulfite in the range of (0%-1.0%), polysulfide in the range of (0%-1%) or thiosulfate in the range of (0%-1.0%);
- wherein the solution is isotonic or near isotonic;
- and,
- wherein the solution is stable for at least four months.
7 more elements
A sterile, stable pharmaceutical composition comprising:
- a solution of deoxygenated water and Na2S,
- wherein the Na2S produces HS−,
- wherein the solution has a pH in the range of 7.8 to 8.2;
- wherein the solution has an osmolarity in the range of 250-330 mOsmol/L;
- wherein the solution further comprises sulfide oxidation products selected from the group consisting of polysulfide, sulfite, sulfate and thiosulfate;
- wherein the oxidation products comprise sulfate in the range of (0%-1.0%), sulfite in the range of (0%-1.0%), polysulfide in the range of (0%-1%) or thiosulfate in the range of (0%-1.0%);
- wherein the solution is stable for at least four months;
- and,
- wherein the solution is isotonic or near isotonic.
6 more elements
A sterile, stable, liquid pharmaceutical composition made by the steps, in any suitable order, comprising:
- making a solution of Na2S by rinsing Na2S.9H2O crystals with deoxygenated, distilled and deionized water;
- bubbling N2, a mixture of N2/CO2, or a mixture of N2/H2S through the solution generating the Na2S that produces HS−, and,
- adjusting the pH of the solution to a pH in the range of 7.5 to 8.5 by adding HCI to the solution;
- wherein said solution has an osmolarity in the range of 250-330 mOsmol/L ;
- wherein said solution further comprises sulfide oxidation products selected from the group consisting of polysulfide, sulfite, sulfate and thiosulfate;
- wherein the oxidation products comprise sulfate in the range of (0%-1.0%), sulfite in the range of (0%-1.0%), polysulfide in the range of (0%-1%) or thiosulfate in the range of (0%-1.0%);
- and,
- wherein said composition is isotonic or near isotonic.
5 more elements
Dependencies are inferred from the claim text.