Buoyant polymer particles for delivery of therapeutic agents to the central nervous system
AssigneeSeacoast Neuroscience, Inc.
InventorsDaniel Pratt, Samuel S. MacAusland, Keith Baker
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Abstract
The invention provides compositions and methods for treating a subject who has suffered from a central nervous system disorder. More particularly, the invention provides sustained polymeric drug delivery systems having a polymer particle, a therapeutic agent, and a buoyancy agent for direct delivery of therapeutic agents into the central nervous system.
Claims14
A method for administering a therapeutic agent within the central nervous system of a subject, the method comprising intrathecally administering a composition to the central nervous system of said subject, wherein said composition comprises a plurality of biodegradable polymer particles having a therapeutic agent and a buoyancy agent contained therein, wherein the buoyancy agent is a gas or an oil, or a combination thereof, and wherein the composition is controllably buoyant within the cerebrospinal fluid to provide targeted delivery of the therapeutic agent within the central nervous system of the subject, wherein the buoyancy agent comprises a hydrofluorocarbon.
Dependencies are inferred from the claim text.