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US 7,923,021 B2Granted
Local delivery method and composition
AssigneeThe University of Memphis Research Foundation
InventorsWarren O. Haggard, Kelly C. Richelsoph
Life of this patent
Estimating the term…
Abstract
This invention provides a rapidly degrading composition for local delivery of a medicament, such as, an antibiotic. Additionally, this invention provides a method that can be used on the battlefield to deliver antibiotics as a preliminary treatment through the use of a rapidly degrading composition.
Claims24
A local delivery composition comprising:
- a paste comprising calcium sulfate dihydrate, a medicament, a mixing solution and a binding agent, wherein said paste is treated to form a pellet, said pellet formulated to dissolve within 24 hours of implantation in a release environment wherein said release environment is selected from the group consisting of an open wound, tissue of a burn patient and a musculoskeletal injury.
A local delivery composition comprising:
- a paste comprising calcium sulfate dihydrate, a medicament, a mixing solution and carboxymethylcellulose, wherein said paste is treated to form a pellet and said medicament is retained in said pellet wherein said pellet substantially dissolves in a release environment within 24 hours of implantation in said release environment.
A method to make a local delivery composition comprising:
- a) mixing calcium sulfate dihydrate, a binding agent and
- a medicament in a mixing solution to form a paste;
- and
- b) evaporating said solution to form a pellet.
1 more element
A local delivery composition comprising:
- a calcium sulfate dihydrate and a binder formulated to dissolve within 24 hours of implantation in a release environment and a medicament wherein said local delivery agent is in the form of a pellet, and made by the process comprising:
- mixing calcium sulfate dihydrate, a binding agent and
- a medicament in a mixing solution to form a paste;
- and evaporating said solution to form a pellet.
1 more element
Dependencies are inferred from the claim text.