Antibiotic/s containing bone substitute material with sustained active substance release

Antibiotic/s containing bone substitute material, comprising a mixture of granules compacted in a mold with a pressing force of at least 30 kN of the following components:

• calcium sulfate dihydrate,
• and at least one member selected from the group consisting of calcium carbonate, β-tricalcium phosphate, calcium hydrogen phosphate, calcium hydrogen phosphate dihydrate, magnesium carbonate, trimagnesium phosphate, magnesium hydroxide and magnesium oxide,
• and at least one member selected from the group consisting of aminoglycoside antibiotics, lincosamide antibiotics, glycopeptide antibiotics, macrolide antibiotics, ketolide antibiotics, nitroimidazoles, fluoroquinolone antibiotics, oxazolidinone antibiotics, steroid antibiotics, and fungicidal/fungistatic antibiotics,
• with the granules being partly or entirely sheathed with a layer of one or more substances selected from the group consisting of glycerol tripalmitate, glycerol tristearate, glycerol trilaurate and 1-hexadecyl alcohol which connects individual granules with each other,
• wherein the compacted mixture has no macropores of pore diameters larger than 50 μm.