Methods for decreasing osteoclast formation or bone resorption using an antibody to osteoprotegerin binding protein
AssigneeAmgen Inc.
InventorWilliam J. Boyle
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Abstract
A novel polypeptide, osteoprotegerin binding protein, involved in osteolcast maturation has been identified based upon its affinity for osteoprotegerin. Nucleic acid sequences encoding the polypeptide, or a fragment, analog or derivative thereof, vectors and host cells for production, methods of preparing osteoprotegerin binding protein, and binding assays are also described. Compositions and methods for the treatment of bone diseases such as osteoporosis, bone loss due to arthritis or metastasis, hypercalcemia, and Paget's disease are also provided.
Claims34
A method of decreasing bone resorption comprising selecting a patient having an increase in the rate of bone resorption over the rate of bone formation, and administering to the patient a composition comprising a monoclonal antibody or binding fragment thereof which specifically binds to an osteoprotegerin binding protein consisting of amino acid residues 1 to 317 as shown in FIG. 4 (SEQ ID NO:39) wherein the monoclonal antibody or binding fragment thereof is an antagonist which decreases the activity of osteoprotegerin binding protein.
A method of decreasing osteoclast formation comprising selecting a patient having an increase in the rate of bone resorption over the rate of bone formation, and administering to the patient a composition comprising a monoclonal antibody or binding fragment thereof which specifically binds to an osteoprotegerin binding protein consisting of amino acid residues 1 to 317 as shown in FIG. 4 (SEQ ID NO:39), wherein the monoclonal antibody or binding fragment thereof is an antagonist which decreases the activity of osteoprotegerin binding protein.
Dependencies are inferred from the claim text.