Adhesive for medical applications and means for haemostasis

An adhesive comprising the following components:

• (a) polymers having at least one free amino group, wherein the polymers are not part of the human body;
• (b) bridge molecules, selected from the group consisting of monocyclic ortho-dihydroxyaromates, monocyclic para-dihydroxyaromates, bicyclic monohydroxyaromates, polycyclic monohydroxyaromates, bicyclic dihydroxyaromates, polycyclic dihydroxyaromates, bicyclic trihydroxyaromates, polycyclic trihydroxyaromates, and mixtures thereof;
• and
• (c) polyphenoloxidases,
• wherein the individual components (b) and (c) are in contact.

A method for closing a wound comprising:

• providing a polymer component having at least one free amino group and crosslinking the polymer component by means of bridge molecules using a polyphenoloxidase component wherein the bridge molecules are selected from the group consisting of monocyclic ortho-dihydroxyaromates, monocyclic para-dihydroxyaromates, bicyclic monohydroxyaromates, polycyclic monohydroxyaromates, bicyclic dihydroxyaromates, polycyclic dihydroxyaromates, bicyclic trihydroxyaromates, polycyclic trihydroxyaromates, and mixtures thereof, the polyphenoloxidase component and the bridge molecules contained in separate chambers;
• discharging the components from each chamber and forming a mixture;
• and
• applying the mixture to the wound.

A kit comprising the following individual components:

• (a) polymers having at least one free amino group;
• (b) bridge molecules, selected from the group consisting of monocyclic ortho-dihydroxyaromates, monocyclic para-dihydroxyaromates, bicyclic dihydroxyaromates, polycyclic dihydroxyaromates, bicyclic trihydroxyaromates, polycyclic trihydroxyaromates, and mixtures thereof;
• and
• (c) polyphenoloxidases,
• wherein the individual components (b) and (c) are not in contact.

An adhesive comprising the following components:

• (a) polymers having at least one free amino group, wherein the polymers are not part of the human body;
• (b) bridge molecules, selected from the group consisting of monocyclic ortho-dihydroxyaromates, monocyclic para-dihydroxyaromates, bicyclic dihydroxyaromates, polycyclic dihydroxyaromates, bicyclic trihydroxyaromates, polycyclic trihydroxyaromates, and mixtures thereof;
• and
• (c) polyphenoloxidases,
• wherein the individual components (b) and (c) are in contact.