Bioprosthetic heart valve with polyphosphazene
AssigneeCelonova Bioscience, Inc.
InventorsThomas A. Gordy, Neng S. Ung, Ulf Fritz, Roman Denk
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Abstract
This disclosure encompasses a bioprosthetic heart valve having a polyphosphazene polymer such as poly[bis(trifluoroethoxy)phosphazene], which exhibits improved antithrombogenic, biocompatibility, and hemocompatibility properties. A method of manufacturing a bioprosthetic heart valve having a polyphosphazene polymer is also described.
Claims24
A bioprosthetic heart valve comprising a biological tissue and a polyphosphazene represented by formula (I):
- wherein
- n is 2 to ∞;
- and
- R1 to R6 are groups which are each selected independently from alkyl, aminoalkyl, haloalkyl, thioalkyl, thioaryl, alkoxy, haloalkoxy, aryloxy, haloaryloxy, alkylthiolate, arylthiolate, alkylsulphonyl, alkylamino, dialkylamino, heterocycloalkyl comprising one or more heteroatoms selected from nitrogen, oxygen, sulfur, phosphorus, or a combination thereof or heteroaryl comprising one or more heteroatoms selected from nitrogen, oxygen, sulfur, phosphorus, or a combination thereof.
A method of manufacturing a bioprosthetic heart valve, comprising
- providing a biological tissue;
- and
- contacting the biological tissue with a polyphosphazene of formula (I):
- wherein
- n is 2 to ∞;
- and
- R1 to R6 are groups which are each selected independently from alkyl, aminoalkyl, haloalkyl, thioalkyl, thioaryl, alkoxy, haloalkoxy, aryloxy, haloaryloxy, alkylthiolate, arylthiolate, alkylsulphonyl, alkylamino, dialkylamino, heterocycloalkyl comprising one or more heteroatoms selected from nitrogen, oxygen, sulfur, phosphorus, or a combination thereof, or heteroaryl comprising one or more heteroatoms selected from nitrogen, oxygen, sulfur, phosphorus, or a combination thereof.
A method of improving the antithrombogenic, biocompatibility, or hemocapatibility properties of a bioprosthetic heart valve, comprising:
- contacting the bioprosthetic heart valve with a polyphosphazene of formula (I):
- wherein
- n is 2 to ∞;
- and
- R1 to R6 are groups which are each selected independently from alkyl, aminoalkyl, haloalkyl, thioalkyl, thioaryl, alkoxy, haloalkoxy, aryloxy, haloaryloxy, alkylthiolate, arylthiolate, alkylsulphonyl, alkylamino, dialkylamino, heterocycloalkyl comprising one or more heteroatoms selected from nitrogen, oxygen, sulfur, phosphorus, or a combination thereof, or heteroaryl comprising one or more heteroatoms selected from nitrogen, oxygen, sulfur, phosphorus, or a combination thereof;
- wherein the polyphosphazene is coated, diffused, impregnated, grafted, or any combination thereof, into or onto the bioprosthetic heart valve.
A bioprosthetic heart valve comprising a mammalian heart valve and a poly-[bis(trifluoroethoxy)phosphazene].
A method of making a bioprosthetic heart valve comprising
- providing a mammalian heart valve;
- and
- contacting the mammalian heart valve with a poly[bis(trifluoroethoxy)-phosphazene];
- wherein the poly[bis(trifluoroethoxy)phosphazene] is coated, diffused, impregnated, grafted, or any combination thereof, into or onto the mammalian heart valve.
Dependencies are inferred from the claim text.