Bipolar trans carotenoid salts and their uses
AssigneeDiffusion Pharmaceuticals LLC
InventorsJohn L. Gainer, Raymond C. Grabiak
Life of this patent
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Abstract
The invention relates to trans carotenoid salt compounds, methods for making them, methods for solubilizing them and uses thereof. These compounds are useful in improving diffusivity of oxygen between red blood cells and body tissues in mammals including humans.
Claims27
A pharmaceutical composition of synthetic trans sodium crocetinate having the structure:
- wherein the purity level of the trans isomer in the composition is such that, under UV-visible analysis, the absorbency of the highest peak which occurs in the visible wave length range divided by the absorbency of the peak which occurs in the UV wave length range is greater than 7.5.
A method of increasing the diffusivity of oxygen in a mammal comprising administering to a mammal a therapeutically effective amount of a bipolar trans carotenoid salt compound having the formula:
- YZ-TCRO-ZY
- where:
- Y=a cation
- Z=a polar group which is associated with the cation, and
- TCRO=trans carotenoid skeleton having pendant groups X, wherein the pendant groups X, which can be the same or different, are a linear or branched group having 10 or less carbon atoms, or a halogen,
- wherein said compound is not trans sodium crocetinate.
A method of treating a mammal, having a disease or condition characterized by hypoxia, comprising administering to such mammal a therapeutically effective amount of a bipolar trans carotenoid salt compound having the formula:
- YZ-TCRO-ZY
- where:
- Y=a cation
- Z=a polar group which is associated with the cation, and
- TCRO=trans carotenoid skeleton having pendant groups X, wherein the pendant groups X, which can be the same or different, are a linear or branched group having 10 or less carbon atoms, or a halogen,
- wherein said compound is not trans sodium crocetinate.
A method of increasing the diffusivity of oxygen in a mammal comprising administering to a mammal a therapeutically effective amount of a composition of synthetic trans sodium crocetinate having the structure:
- wherein the purity level of the trans isomer in the composition is such that, under UV-visible analysis, the absorbency of the highest peak which occurs in the visible wave length range divided by the absorbency of the peak which occurs in the UV wave length range is greater than 7.5.
A method of treating a mammal having a disease or condition characterized by hypoxia comprising administering to such mammal a therapeutically effective amount of a composition of synthetic trans sodium crocetinate having the structure:
- wherein the purity level of the trans isomer in the composition is such that under UV-visible analysis, the absorbency of the highest peak which occurs in the visible wave length range divided by the absorbency of the peak which occurs in the UV wave length range is greater than 7.5.
A method of increasing endurance in a mammal during physical activity comprising administering to said mammal a therapeutically effective amount of a bipolar trans carotenoid salt compound having the formula:
- YZ-TCRO-ZY
- where:
- Y=a cation
- Z=a polar group which is associated with the cation, and
- TCRO=trans carotenoid skeleton having pendant groups X, wherein the pendant groups X, which can be the same or different, are a linear or branched group having 10 or less carbon atoms, or a halogen.
A method of increasing aerobic metabolism in a mammal comprising administering to said mammal a therapeutically effective amount of a bipolar trans carotenoid salt compound having the formula:
- YZ-TCRO-ZY
- where:
- Y=a cation
- Z=a polar group which is associated with the cation, and
- TCRO=trans carotenoid skeleton having pendant groups X, wherein the pendant groups X, which can be the same or different, are a linear or branched group having 10 or less carbon atoms, or a halogen.
A method of treating anemia in a mammal comprising administering to a mammal in need of treatment a therapeutically effective amount of a bipolar trans carotenoid salt compound having the formula:
- YZ-TCRO-ZY
- where:
- Y=a cation
- Z=a polar group which is associated with the cation, and
- TCRO=trans carotenoid skeleton having pendant groups X, wherein the pendant groups X, which can be the same or different, are a linear or branched group having 10 or less carbon atoms, or a halogen.
A method of treating stroke comprising administering to a mammal in need of treatment a therapeutically effective amount of a bipolar trans carotenoid compound having the formula:
- YZ-TCRO-ZY
- where:
- Y=a cation
- Z=a polar group which is associated with the cation, and
- TCRO=trans carotenoid skeleton having pendant groups X, wherein the pendant groups X, which can be the same or different, are a linear or branched group having 10 or less carbon atoms, or a halogen.
A method of reducing the amount of ischemia resulting from surgery in a mammal comprising administering to a mammal before, during, or after surgery a therapeutically effective amount of a bipolar trans carotenoid salt compound having the formula:
- YZ-TCRO-ZY
- where:
- Y=a cation
- Z=a polar group which is associated with the cation, and
- TCRO=trans carotenoid skeleton having pendant groups X, wherein the pendant groups X, which can be the same or different, are a linear or branched group having 10 or less carbon atoms, or a halogen.
A method of treating a mammal at risk of a disease or condition characterized by hypoxia comprising administering to such mammal a therapeutically effective amount of a bipolar trans carotenoid salt compound having the formula
- YZ-TCRO-ZY
- where:
- Y=a cation
- Z=a polar group which is associated with the cation, and
- TCRO=trans carotenoid skeleton having pendant groups X, wherein the pendant groups X, which can be the same or different, are a linear or branched group having 10 or less carbon atoms, or a halogen.
Dependencies are inferred from the claim text.