Monoclonal antibodies against orthopoxviruses
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsZhaochun Chen, Patricia Earl, Bernard Moss, Suzanne U. Emerson, Robert H. Purcell
Life of this patent
Estimating the term…
Abstract
The present invention relates to monoclonal antibodies that bind or neutralize Orthopoxviruses. The invention provides such antibodies, fragments of such antibodies retaining B5 or A33 binding ability, fully human antibodies retaining B5 or A33 binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
Claims15
A purified monoclonal antibody comprising a fully humanized or humanized chimpanzee monoclonal antibody that binds to a conformational epitope of B5 antigen, wherein said purified monoclonal antibody comprises a heavy chain variable region with the amino acid sequence of SEQ ID NO:1 and a light chain variable region with the amino acid sequence of SEQ ID NO:9.
A purified monoclonal antibody that binds a conformational epitope of B5 antigen to which anti-B5 8AH8AL antibody binds, wherein said anti-B5 8AH8AL antibody comprises a heavy chain CDR1 region having the amino acid sequence of SEQ ID NO:3, a heavy chain CDR2 region having the amino acid sequence of SEQ ID NO:5, a heavy chain CDR3 region having the amino acid sequence of SEQ ID NO:7, a light chain CDR1 region having the amino acid sequence of SEQ ID NO:11, a light chain CDR2 region having the amino acid sequence of SEQ ID NO:13 and a light chain CDR3 region having the amino acid sequence of SEQ ID NO:15.
A purified anti-B5 8AH8AL antibody, wherein said anti-B5 8AH8AL antibody comprises a heavy chain CDR1 region having the amino acid sequence of SEQ ID NO:3, a heavy chain CDR2 region having the amino acid sequence of SEQ ID NO:5, a heavy chain CDR3 region having the amino acid sequence of SEQ ID NO:7, a light chain CDR1 region having the amino acid sequence of SEQ ID NO:11, a light chain CDR2 region having the amino acid sequence of SEQ ID NO:13 and a light chain CDR3 region having the amino acid sequence of SEQ ID NO:15.
Dependencies are inferred from the claim text.