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US 7,914,783 B2Granted
Pharmacological vitreolysis
AssigneeThromboGenics NV
InventorsSteve Pakola, Marc De Smet
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AssigneeThromboGenics NV
InventorsSteve Pakola, Marc De Smet
Estimating the term…
Methods of treating or preventing a disorder, or a complication of a disorder, of an eye of a subject, comprising contacting a vitreous and/or aqueous humor with a composition comprising a truncated form of plasmin comprising a catalytic domain of plasmin (TPCD) are disclosed. TPCDs include, but are not limited to, miniplasmin, microplasmin and derivatives and variants thereof. The methods of the invention can be used to reduce the viscosity of the vitreous, liquefy the vitreous, induce posterior vitreous detachment, reduce hemorrhagic blood from the eye, clear or reduce materials toxic to the eye, clear or reduce intraocular foreign substances from the eye, increase diffusion of a composition administered to an eye, reduce extraretinal neovascularization and any combinations thereof. The method can be used in the absence of, or as an adjunct to, vitrectomy.
A method of liquefying a vitreous and/or inducing posterior vitreous detachment of an eye of a subject who is at a risk of developing vitreomacular traction, a macular hole, retinal detachment, a retinal tear, retinal neovascularization, retinal hemorrhage, or macular edema, as a complication of a disorder or of incomplete posterior vitreous detachment of an eye of the subject, comprising contacting a vitreous and/or an aqueous humor in the eye of the subject with an effective amount of a composition comprising microplasmin, wherein the method results in liquefying a vitreous and/or inducing posterior vitreous detachment of the eye of the subject.
A method of preventing development of vitreomacular traction, a macular hole, retinal detachment, a retinal tear, retinal neovascularization, retinal hemorrhage, or macular edema, as a complication of a disorder or of incomplete posterior vitreous detachment of an eye of a subject, comprising contacting a vitreous and/or an aqueous humor in the eye of the subject with an effective amount of a composition comprising microplasmin, wherein the method results in vitreous liquefaction and/or posterior vitreous detachment in the eye of the subject.
A method of delaying the onset or reducing the incidence of a disorder of an eye of a subject, wherein the disorder is associated with vitreous contraction or neovascularization into the vitreous, comprising contacting a vitreous and/or aqueous humor in the eye of the subject with an effective amount of a composition comprising microplasmin, wherein the method results in vitreous liquefaction and/or posterior vitreous detachment in the eye of the subject, thereby delaying the onset or reducing the incidence of the disorder.
A method of inhibiting a complication in central or branch retinal vein occlusion of an eye of a subject, comprising contacting a vitreous and/or aqueous humor in the eye of the subject with an effective amount of a composition comprising microplasmin, wherein the method results in vitreous liquefaction and/or posterior vitreous detachment in the eye of the subject, thereby inhibiting a complication in central or branch retinal vein occlusion.
Dependencies are inferred from the claim text.