Fc receptor modulating compounds and compositions
AssigneeTrillium Therapeutics Inc.
InventorsMark Phillip Hogarth, Geoffrey Allan Pietersz, Gerard Peter Moloney
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Abstract
The present invention provides compounds capable of binding to an Fc receptor and modulating Fc receptor activity comprising a core lipophilic group in the form of an Aryl ring substituted with a group rich in p-electrons. The invention further provides for a method of treating an autoimmune disease involving Fc receptor activity using such compounds. A method for obtaining a compound which modulates Fc receptor activity is also provided, the method comprising: (a) providing or designing compounds having structural characteristics to fit in the groove of the FcγRIIa structure; and (b) screening the compounds for modulating activity on the Fc receptor.
Claims14
A compound having the general formula II:
- wherein
- R6, R7, R9 and R10 are H and R1, R2, R3, R4 and R5, are each selected from H, CO2H and CN, but wherein no more than one of R1, R2, R3, R4 and R5 is CO2H or CN and R8 is CO2H or CN.
Dependencies are inferred from the claim text.