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US 7,910,579 B2Granted
Benzoxazole derivatives
AssigneeTohoku University
InventorsYukitsuka Kudo, Syozo Furumoto, Nobuyuki Okamura
Life of this patent
Estimating the term…
Abstract
It is intended to provide a benzoxazole derivative or a pharmaceutically acceptable salt or solvate thereof which is useful in the early diagnosis of a conformation disease; a composition or a kit containing the same for diagnosing a conformation disease; a medical composition for treating and/or preventing a conformation disease; and so on.
Claims29
A compound, pharmaceutically acceptable salt or solvate thereof represented by formula (I):
- wherein
- R1 and R2 are independently hydrogen atom, lower alkyl group respectively, or cycloalkyl group, or 3- to 8-membered nitrogen-containing aliphatic ring formed by R1, R2 and a nitrogen atom bonded thereto, together (carbon atoms which constitute the nitrogen-containing aliphatic ring may be substituted with nitrogen atom, sulfur atom or oxygen atom, and when the carbon atom is substituted with nitrogen atom, the nitrogen atom may be substituted with lower alkyl group),
- X1 and X2 are each independently denotes nitrogen atom, sulfur atom, or oxygen atom,
- R3 is —O— lower alkyl group (the alkyl group is substituted with halogen atom, and furthermore may be optionally substituted hydoxy group), and
- m is an integer of 1 to 3
- provided that the compounds are excluded wherein R3 is a —O— lower alkyl group substituted with only halogen atom, and R1 and R2 are each independently hydrogen atom or lower alkyl group.
3 more elements
A compound, pharmaceutically acceptable salt or solvate thereof represented by formula (I′)
- wherein
- R1 and R2 are independently hydrogen atom, lower alkyl group respectively, or cycloalkyl group, or 3- to 8-membered nitrogen-containing aliphatic ring formed by R1, R2 and a nitrogen atom bonded thereto, together (carbon atoms which constitute the nitrogen-containing aliphatic ring may be substituted with nitrogen atom, sulfur atom or oxygen atom, and when the carbon atom is substituted nitrogen atom, the nitrogen atom may be substituted with lower alkyl group),
- X1 and X2 are each independently nitrogen atom, sulfur atom, or oxygen atom,
- R4 is —O— lower alkyl group (the alkyl group may be substituted with tosyl group, and furthermore may be substituted with hydoxy group), and
- m is an integer of 1 to 3]
- provided that the compounds are excluded wherein R3 is a —O— lower alkyl group substituted with only halogen atom, and R1 and R2 are each independently denotes hydrogen atom or lower alkyl group.
3 more elements
Dependencies are inferred from the claim text.