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US 7,906,659 B2Granted
Carbocyclic and oxacarbocyclic fumaric acid oligomers
AssigneeBiogen Idec International GmbH
InventorsRajendra Kumar Joshi, Hans-Peter Strebel
Life of this patent
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Abstract
The present invention relates to certain carbocyclic and oxacarbocyclic fumaric acid oligomers and the use thereof for preparing a pharmaceutical preparation as well of pharmaceutical preparations containing these compounds.
Claims18
An oxacarbocyclic fumaric acid oligomer of the following formula (IV)
- wherein the radicals R1 and R2 are the same or different and are independently chosen from amine radicals (—NR3R4), amino acid radicals (—NH—CH(COOH)-R6), peptide radicals having 2 to 100 amino acids, alcohol radicals (—OR5) and a hydroxyl radical,
- n is an integer from 2 to 10,
- the radicals R3 and R4 are the same or different and are independently chosen from hydrogen, C1-24 alkyl radicals, a phenyl radical and C6-10 aralkyl radicals,
- the radical R5 is chosen from hydrogen, C1-24 alkyl radicals, a phenyl radical and C6-10 aralkyl radicals,
- and the radical R6 represents a side chain of a natural or synthetic amino acid.
2 more elements
A pharmaceutical preparation comprising an oligomer of formula (IV):
- wherein the radicals R1 and R2 are the same or different and are independently chosen from amine radicals (—NR3R4), amino acid radicals (—NH—CH(COOH)-R6), peptide radicals having 2 to 100 amino acids, alcohol radicals (—OR5) and a hydroxyl radical,
- n is an integer from 2 to 10,
- the radicals R3 and R4 are the same or different and are independently chosen from hydrogen, C1-24 alkyl radicals, a phenyl radical and C6-10 aralkyl radicals,
- the radical R5 is chosen from hydrogen, C1-24 alkyl radicals, a phenyl radical and C6-10 aralkyl radicals,
- and the radical R6 represents a side chain of a natural or synthetic amino acid;
- and at least one excipient.
3 more elements
A method for preparing a pharmaceutical preparation comprising admixing an oligomer of formula (IV):
- wherein the radicals R1 and R2 are the same or different and are independently chosen from amine radicals (—NR3R4), amino acid radicals (—NH—CH(COOH)-R6), peptide radicals having 2 to 100 amino acids, alcohol radicals (—OR5) and a hydroxyl radical,
- n is an integer from 2 to 10,
- the radicals R3 and R4 are the same or different and are independently chosen from hydrogen, C1-24 alkyl radicals, a phenyl radical and C6-10 aralkyl radicals,
- the radical R5 is chosen from hydrogen, C1-24 alkyl radicals, a phenyl radical and C6-10 aralkyl radicals,
- and the radical R6 represents a side chain of a natural or synthetic amino acid,
- with at least one excipient.
3 more elements
Dependencies are inferred from the claim text.