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US 7,906,345 B2Granted
Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsShan X Wang, Robert L White, Chris D Webb, Guanxiong Li
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Abstract
Magnetic nanoparticles and methods for their use in detecting biological molecules are disclosed. The magnetic nanoparticles can be attached to nucleic acid molecules, which are then captured by a complementary sequence attached to a detector, such as a spin valve detector or a magnetic tunnel junction detector. The detection of the bound magnetic nanoparticle can be achieved with high specificity and sensitivity.
Claims21
A method of detecting a complex, the method comprising:
- providing a first molecule bonded to at least one magnetizable nanoparticle;
- providing a second molecule bonded to a substrate;
- contacting the first molecule to the second molecule under conditions suitable for selective binding of the first molecule to the second molecule to form a complex;
- and
- detecting the complex, wherein said detecting comprises applying a DC bias field and then an AC tickling field sufficient to cause a detectable signal.
2 more elements
Dependencies are inferred from the claim text.