Biomarker normalization
AssigneeThe Regents of the University of California
InventorBenjamin Sullivan
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Abstract
In accordance with the invention, a fluid sample is measured with a tear film measuring system that includes a processing device that receives a sample chip comprising a sample region configured to contain an aliquot volume of sample fluid, the processing device configured to perform analyses of osmolarity and of one or more biomarkers within the sample fluid, wherein the analysis of biomarkers includes normalization of biomarker concentration values.
Claims37
A fluid measuring system, the system comprising a processing device that receives a sample chip comprising a sample region configured to contain an aliquot volume of sample fluid, the processing device configured to perform analyses of the osmolarity of the sample fluid and of one or more biomarkers within the sample fluid, wherein the analysis of the one or more biomarkers includes normalization of biomarker concentration values.
A method of measuring a sample fluid, the method comprising:
- receiving an output signal from a sample region of a sample chip that is configured to produce an osmolarity output signal that indicates energy properties of an aliquot volume of the sample fluid, wherein the osmolarity output signal is correlated with the osmolarity of the sample fluid;
- receiving an output signal from the sample region of the sample chip that is configured to produce a biomarker output signal that indicates chemical properties of the sample fluid, wherein the biomarker output signal is correlated with biomarker concentration values of the sample fluid;
- processing the osmolarity output signal to produce an osmolarity value for the sample fluid and processing the biomarker output signal to produce a biomarker concentration value for the sample fluid;
- and determining an Adjusted Biomarker Level that provides normalization of biomarker concentration values.
Dependencies are inferred from the claim text.