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US 7,902,319 B2Granted
Unsymmetrical aromatic ether diacids and absorbable polymers therefrom
AssigneeBezwada Biomedical, LLC
InventorRao S. Bezwada
Life of this patent
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Abstract
The present invention relates to compounds and compositions of formula I, which are unsymmetrical aromatic ether diacids, and polymers formed from the same. [R′—(Y)p—O]q—Ar—[O—(X)r—R′]s I The compounds are expected to be useful in a variety of medical and/or cosmetics applications. Polymers formed from the functionalized unsymmetrical aromatic ether diacids are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range.
Claims34
A compound of formula I or a pharmaceutically acceptable salt thereof:
- [R′—(Y)p—O]q—Ar—[O—(X)r—R′]s I
- wherein:
- Ar is the aromatic portion of a diphenol;
- X and Y are independently selected from:
- —CH2COO—;
- —CH(CH3)COO—;
- —CH2CH2OCH2COO—;
- —CH2CH2CH2CH2CH2COO—;
- —(CH2)yCOO— where y is independently selected from 2-4 and 6-24;
- and
- —(CH2CH2O)zCH2COO— where z is independently selected from 2-24;
- provided that the groups represented by [R′—(Y)p—O]q— and —[O—(X)r—R′]s are different from one another;
- R′ is selected from H, benzyl, and C1-6 alkyl;
- p is selected from 1, 2, 3, 4, 5, and 6;
- q is selected from 1, 2, and 3;
- r is selected from 1, 2, 3, 4, 5, and 6;
- and
- s is selected from 1, 2, and 3.
15 more elements
Dependencies are inferred from the claim text.