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US 7,894,999 B2Granted
Systems and methods for identifying Replikin Scaffolds and uses of said Replikin Scaffolds
OwnerSamuel Bogoch, Elenore S. Bogoch +2inventors
InventorsSamuel Bogoch, Elenore S. Bogoch, Samuel Winston Bogoch, Anne-Elenore Bogoch Borsanyi
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Abstract
The present invention provides a new class of peptides related to rapid replication and high human mortality, and their use in diagnosing, preventing and treating disease including vaccines and therapeutics for emerging viral diseases and methods of identifying the new class of peptides and related structures.
Claims8
A method of identifying a series of peptide sequences as Replikin Scaffold peptides in a virus or organism comprising:
- isolating a plurality of peptides or polypeptides from one or more isolates of a virus, one or more isolates of a strain of virus, or one or more isolates of an organism,
- analyzing the amino acid sequence of each peptide or polypeptide of the plurality of peptides, and
- identifying a series of peptide sequences within the analyzed amino acid sequences as Replikin Scaffold peptides if each member of the series of identified peptide sequences consists of about 16 to about 30 amino acids and comprises
- (1) a terminal lysine and a lysine immediately adjacent to said terminal lysine;
- (2) a terminal histidine and a histidine immediately adjacent to said terminal histidine,
- (3) a lysine within about 6 to about 10 amino acids from another lysine;
- and
- (4) at least 6% lysines,
- wherein the terminal lysines and terminal histidines that define the Replikin Scaffold peptides within said series of Replikin Scaffold peptides are conserved across said different isolates of a virus, a strain of virus, or organism.
6 more elements
Dependencies are inferred from the claim text.