Interfering RNA molecules
AssigneeSilence Therapeutics GmbH
InventorsKlaus Giese, Jörg Kaufmann, Anke Klippel-Giese
Life of this patent
Estimating the term…
Abstract
The present invention is related to a ribonucleic acid comprising a double stranded structure whereby the double-stranded structure comprises a first strand and a second strand, whereby the first strand comprises a first stretch of contiguous nucleotides and whereby said first stretch is at least partially complementary to a target nucleic acid, and the second strand comprises a second stretch of contiguous nucleotides whereby said second stretch is at least partially identical to a target nucleic acid, and whereby the double stranded structure is blunt ended.
Claims11
A nucleic acid molecule comprising a first strand and a second strand,
- wherein said first strand comprises a first stretch that is complementary to a target nucleic acid,
- wherein said second strand comprises a second stretch that is the same length as said first stretch and is complementary to said first stretch,
- wherein said first strand and said second strand form a double-stranded structure comprising said first stretch and said second stretch,
- wherein said first stretch and said second stretch each comprises contiguous alternating single 2′-O-methyl modified ribonucleotides, said single 2′-O-methyl modified ribonucleotides alternate with unmodified or modified ribonucleotides and the 2′-O-methyl modified ribonucleotides of said first strand are shifted by one ribonucleotide relative to the 2′-O-methyl modified ribonucleotides of the second strand, and
- wherein each stretch consists of at least 17 and fewer than 30 ribonucleotides.
Dependencies are inferred from the claim text.