Procedure for the determination of the activity of the protease which activates factor VII from protein solutions
AssigneeCSL Behring GmbH
InventorsJuergen Roemisch, Annette Feussner, Hans-Arnold Stoehr
Life of this patent
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Abstract
The present application relates to procedures for the determination of the activity of the protease which activates factor VII, also known as factor VII activating protease or FSAP. The application also relates to a method of detecting whether an individual has increased or lowered activity in the protease which activates factor VII compared to at least one standard sample, wherein the increased or lowered activity indicates an increased risk for disease or cardiovascular complications.
Claims19
A method of detecting whether an individual has increased or lowered activity of the protease that activates blood clotting factor VII compared to at least one standard sample, comprising:
- (a) obtaining a body fluid sample from the individual,
- (b) determining the activity of the protease that activates blood clotting factor VII in the sample from the individual,
- (c) comparing the protease activity of the protease in the sample from the individual to the protease activity of the at least one standard sample, and
- (d) determining from (c) whether or not the individual has an increased or lowered activity of the protease that activates blood clotting factor VII compared to the at least one standard sample,
- wherein said increased activity indicates that the individual is suffering from a cardiac infarct or from stable or unstable angina, and wherein said lowered activity indicates that the individual has an increased risk of thrombosis.
A method of detecting whether a pregnant individual has increased activity of the protease that activates blood clotting factor VII compared to at least one standard sample, comprising:
- (a) obtaining a body fluid sample from the individual,
- (b) determining the activity of the protease that activates blood clotting factor VII in the sample,
- (c) comparing the protease activity of the protease in the sample from the individual to the protease activity of the at least one standard sample, and
- (d) determining from (c) whether or not the individual has an increased activity of the protease that activates blood clotting factor VII compared to the at least one standard sample,
- wherein an increased level of protease activity compared to the at least one standard sample indicates a reduced risk of thromboembolic complications.
A method of detecting whether an individual has 30-50% lower activity of the protease that activates blood clotting factor VII compared to at least one standard sample, comprising:
- (a) obtaining a body fluid sample from the individual,
- (b) determining the activity of the protease that activates blood clotting factor VII in the sample,
- (c) comparing the protease activity in the sample from the individual to the protease activity of the at least one standard sample, and
- (d) determining from (c) whether or not the individual has 30-50% lower activity of the protease that activates blood clotting factor VII compared to the at least one standard sample,
- wherein said 30-50% lower activity indicates an increased risk for thrombosis.
Dependencies are inferred from the claim text.