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US 7,892,553 B2Granted
Materials and methods to reduce low density lipoprotein cholesterol
AssigneeUniversity of South Florida
InventorsShyam S. Mohapatra, Arun Kumar
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Abstract
The present invention pertains to nanoparticles, comprising a metal and/or polymer core, with 7-alpha hydroxylase, or an enzymatically active fragment thereof, nicotinamide adenine dinucleotide (NADH) and antibodies, or antibody fragments, specific for low density lipoprotein (LDL), attached to the core. The invention also concerns methods for reducing LDL cholesterol in a human or animal subject by administering nanoparticles of the invention. In a preferred embodiment, both circulating LDL and plasma cholesterol levels are reduced in the subject.
Claims10
A nanoparticle comprising:
- a. a core comprising a metal, a polymer, or a combination thereof;
- b. a low-density lipoprotein (LDL) binding agent attached to said core;
- c. 7-α hydroxylase or an enzymatically active fragment thereof attached to said core;
- and
- d. nicotinamide adenine dinucleotide (NADH) attached to said core.
2 more elements
Dependencies are inferred from the claim text.