Analysis of optical data with the aid of histograms
AssigneeRoche Diagnostics Operations, Inc.
InventorsWolfgang Petrich, Hans-Peter Haar, Jean-Michel Asfour, Gerrit Kocherscheidt
Life of this patent
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Abstract
A system for determining the concentration of an analyte in a liquid sample comprising a detection unit for detecting light intensities which are radiated from subareas of a detection area of a test element as well as an evaluation unit which determines a frequency distribution for the detected light intensities wherein the frequency distribution has at least one first maximum caused by unwetted subareas or at least one reference area and a second maximum caused by wetted subareas and selects at least one light intensity on the basis of the frequency distribution and determines the concentration of the analyte from the at least one selected light intensity.
Claims19
A system for determining the concentration of an analyte in a liquid sample comprising:
- a detection unit for detecting light intensities which are radiated from subareas of a detection area of a test element;
- and
- an evaluation unit which determines a frequency distribution for the detected light intensities wherein the frequency distribution has at least one first maximum caused by one of at least one unwetted subarea of the detection area and at least one reference area of the test element and a second maximum caused by subareas of the detection area wetted by a sample and at least one light intensity is selected on the basis of at least one characteristic of the frequency distribution and the concentration of the analyte is determined from the at least one selected light intensity.
A method for determining the concentration of an analyte in a liquid comprising the steps of:
- applying a liquid to a detection area of a test element;
- detecting light intensities of the light radiated from subareas of the detection area;
- determining a frequency distribution of the detected light intensities, wherein the frequency distribution has at least one first maximum caused by one of at least one unwetted subarea of the detection area and at least one reference area of the test element and a second maximum caused by wetted subareas of the detection area;
- and
- calculating the concentration of the analyte on the basis of at least one light intensity which was selected on the basis of at least one characteristic of the frequency distribution.
An instrument for determining the concentration of an analyte in a liquid sample comprising:
- a detection unit for detecting light intensities which are radiated from subareas of a detection area of a test element;
- and
- an evaluation unit which determines the concentration of the analyte in the liquid sample based on a frequency distribution for the detected light intensities wherein the frequency distribution has at least one first maximum caused by one of at least one unwetted subarea of the detection area and at least one reference area of the test element and a second maximum caused by wetted subareas of the detection area, and the concentration is determined based on at least one light intensity which is selected on the basis of at least one characteristic of the frequency distribution;
- wherein the evaluation unit is integrated into the detection unit.
Dependencies are inferred from the claim text.