Back to results
US 7,888,527 B2Granted
Aryl amide sphingosine 1-phosphate analogs
AssigneeUniversity of Virginia Patent Foundation
InventorsKevin R. Lynch, Timothy L. Macdonald, Jeremy J. Clemens, Michael D. Davis
Life of this patent
Estimating the term…
Abstract
The present invention provides compounds that have antagonist activity at the S1P1 and/or S1P3 receptors. These compounds have enhanced selectivity and potency at the S1P1 and/or S1P3 receptors.
Claims10
A compound having formula (I):
- wherein X and Y taken together with the atom to which they are attached form a keto group;
- R1 is hydrogen, halo, tri-fluoromethyl, (C1-C6)-alkyl, (C1-C6) alkyl substituted with halo, hydroxy, alkoxy, or cyano;
- R2 is (C1-C10)alkyl, (C3-C8)-cycloalkyl substituted alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, aryl, alkyl substituted aryl, arylalkyl or aryl substituted arylalkyl;
- or
- a pharmaceutically acceptable ester or salt thereof.
2 more elements
Dependencies are inferred from the claim text.