Preparation of platinum(II) complexes
AssigneePlatco Technologies (Proprietary) Limited
InventorJan Gysbert Hermanus Du Preez
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Abstract
This invention relates to a method for the preparation of a platinum(II) complex containing a neutral bidentate ligand, such as oxaliplatin. The method includes the step of reacting a halogenoplatinum complex containing a neutral bidentate ligand with an oxalate salt in a solvent, wherein more than 1 g/L of the oxalate salt is soluble in the solvent. The invention also relates to new platinum(II) complexes.
Claims102
A method for the preparation of a platinum(II) complex containing a neutral bidentate ligand, the method including the step of reacting a halogenoplatinum(II) complex containing a neutral bidentate ligand with a water soluble metal oxalate other than silver oxalate in a solvent, wherein the neutral bidentate ligand is reacted with the oxalate at a molar ratio of greater than 1:1.
A method for the preparation of a platinum(II) complex containing a neutral bidentate ligand, the method including the step of reacting a halogenoplatinum(II) complex containing a neutral bidentate ligand with an organic oxalate salt in a solvent.
A method for the preparation of a platinum(II) complex containing a neutral bidentate ligand, the method including the step of reacting a halogenoplatinum complex containing a neutral bidentate ligand with an oxalate salt in a solvent, where the solvent is a non-aqueous solvent or a mixed solvent system.
Dependencies are inferred from the claim text.