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US 7,888,512 B2Granted
Synthesis of nicotine derivatives from nicotine
AssigneeNorth Carolina State University
InventorsDaniel L. Comins, Emilie Despagnet Smith
Life of this patent
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Abstract
Methods of synthesizing nicotine analogs and derivatives are described. In some embodiments the methods utilize an alkyl or aryl silyl-substituted nicotine analog intermediate. Intermediates useful for the synthesis of nicotine and nicotine analogs are also described.
Claims16
An enantiopure compound of Formula iv:
- wherein:
- R2 and R6 are each independently selected from the group consisting of H, alkyl, aryl, alkenyl, alkynyl, alkoxy, and halo,
- R5a is a substituted or unsubstituted aryl;
- and
- R7 is selected from the group consisting of consisting of H and alkyl.
2 more elements
A compound of Formula iv:
- wherein:
- R2 is H and R6 is alkoxy;
- R5a is a substituted or unsubstituted aryl;
- and
- R7 is selected from the group consisting of consisting of H and alkyl.
2 more elements
An enantiopure compound of Formula iv:
- wherein:
- R2 and R6 are each independently H or alkyl,
- R5a is a substituted or unsubstituted aryl;
- and
- R7 is H or alkyl.
2 more elements
Dependencies are inferred from the claim text.