Outer membrane protein of Ehrlichia canis and Ehrlichia chaffeensis
AssigneeThe Ohio State University Research Foundation
InventorsYasuko Rikihisa, Norio Ohashi
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AssigneeThe Ohio State University Research Foundation
InventorsYasuko Rikihisa, Norio Ohashi
Estimating the term…
Diagnostic tools for for serodiagnosing ehrlichiosis in mammals, particularly in members of the Canidae family and in humans are provided. The diagnostic tools are a group of outer membrane proteins of E. chaffeensis and variants thereof, referred to hereinafter as the “OMP proteins”, a group of outer membrane proteins of E. canis and variants thereof referred to hereinafter as the “P30F proteins”, and antibodies to the OMP proteins and the P30F proteins. The OMP proteins of E. chaffeensis encompass OMP-1, OMP-1A, OMP1-B, OMP-1C, OMP1-D, OMP1-E, OMP1-F, OMP1-H, OMP-1R, OMP-1S, OMP-1T, OMP-1U, OMP-1V, OMP-1W, OMP-1X, OMP-1Y and OMP-1Z. The P30F proteins of E. canis encompass P30, P30a, P30-1, P30-2, P30-3, P304, P30-5, P30-6, P30-7, P30-8, P30-9, P30-10, P30-11, and P30-12. Isolated polynucleotides that encode the E. chaffeensis OMP proteins and isolated polynucleotides that encode the E. canis P30F protein are also provided. The present invention also relates to kits containing reagents for diagnosing human ehrlichiosis and canine ehrlichiosis, and to immunogenic compositions containing one or more OMP proteins or P30F proteins.
An isolated or purified polypeptide comprising a sequence chosen from the following:
An isolated or purified polypeptide, wherein said polypeptide comprises a sequence that is at least 95% identical to an E. canis sequence chosen from:
An isolated polypeptide wherein said polypeptide comprises a sequence which is at least 95% identical to the sequence amino acid 33 through amino acid 224 of SEQ ID NO:
Dependencies are inferred from the claim text.