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AssigneeWyeth
InventorsFrank S. Walsh, Margaret M. Zaleska, David S. Howland, Lioudmila Tchistiakova, Riyez Karim, Pamela Kelley, Xiang-Yang Tan, Seung Poon Kwak, Menelas N. Pangalos
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The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
An isolated antibody that binds GDF-8, comprising a heavy chain variable region comprising three complementarity determining regions (CDRs) comprising the amino acid sequences of SEQ ID NO:
An isolated antibody that binds GDF-8, comprising a heavy chain variable region wherein said heavy chain variable region comprises a CDR1 comprising the amino acid sequence of SEQ ID NO:
An isolated antibody capable of binding GDF-8, comprising the amino acid sequences of SEQ ID NO:
An isolated antibody capable of binding GDF-8 comprising a heavy chain variable region comprising the amino acid sequence encoded by the DNA sequence of SEQ ID NO:
An isolated antibody capable of binding GDF-8 comprising a heavy chain variable region comprising the amino acid sequence encoded by the DNA sequence of SEQ ID NO:
An isolated antibody capable of binding GDF-8 said antibody comprising the amino acid sequences of SEQ ID NO:7 (VH) and SEQ ID NO:9 (VL).
An isolated antibody capable of binding GDF-8 wherein the antibody comprises:
An isolated antibody produced by a method comprising culturing a host cell comprising a polynucleotide encoding an antibody that binds to GDF-8, wherein the polynucleotide comprises DNA sequences selected from the group consisting of a) SEQ ID NO:2 and SEQ ID NO:4, and b) SEQ ID NO:6 and SEQ ID NO:8, expressing the antibody and recovering the antibody expressed by the host cell.
Dependencies are inferred from the claim text.