Humanized antibodies to interferon alpha receptor-1 (IFNAR-1)

A humanized antibody or humanized antibody fragment that specifically binds IFN alpha receptor-1, comprising:

• a) a heavy chain variable region comprising the CDR1 amino acid sequence of (SEQ ID NO:1, the CDR2 amino acid sequence of SEQ ID NO:2), the CDR3 amino acid sequence of SEQ ID NO:3 or SEQ ID NO:3 consisting of a single amino acid substitution, and at least one variable region residue, or combination of residues, chosen from:
• an alanine at residue 24H;
• a methionine or an alanine at residue 29H;
• an isoleucine at residue 37H and a threonine at residue 40H;
• a proline at residue 40H;
• a lysine at residue 71H;
• a leucine at 78H, wherein the variable region residue is identified utilizing the Kabat numbering system;
• and
• (b) a light chain variable region comprising the CDR1 amino acid sequence of SEQ ID NO:4, the CDR2 amino acid sequence of SEQ ID NO:5, and the CDR3 amino acid sequence of SEQ ID NO:6, and at least one variable region residue chosen from:
• an alanine at residue 19L;
• a leucine at residue 37L;
• an alanine at residue 46L;
• an isoleucine at residue 58L;
• an aspartic acid at residue 70L;
• and a threonine at residue 83L, wherein the variable region residue is identified utilizing the Kabat numbering system.