Ovarian cancer-associated antibodies and kits
AssigneeCorixa Corporation
InventorsChaitanya S Bangur, Marc W Retter, Gary R Fanger, Paul Hill
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Abstract
Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.
Claims9
An isolated antibody or antigen binding fragment thereof, which specifically binds to the O8E polypeptide of SEQ ID NO:
- 392 at an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 396-400, 403-406, 409 and 413-415.
An isolated antibody or antigen binding fragment thereof, which specifically binds to the O8E polypeptide of SEQ ID NO:
- 392 at an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 398, 414 and 415.
A method for making an antibody comprising immunizing a mammal with a peptide having an amino acid sequence selected from any one of SEQ ID NOs:
- 396-400, 403-406, 409 and 413-415.
Dependencies are inferred from the claim text.