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US 7,888,474 B2Granted
HDM2 polypeptides
AssigneeSchering Corporation
InventorsThomas E. Hesson, Hung V. Le, Yao Ma, Vincent S. Madison, Anthony F. Mannarino, Paul Reichert, Gerald W. Shipps, Jr., Corey O. Strickland, Shahriar Shane Taremi, Yaolin Wang, Rumin Zhang, Jose Duca
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Abstract
The present invention relates to HDM2 polypeptides and mutants thereof which are complexed with various compounds, e.g., HDM2 inhibitors.
Claims8
A complex comprising an isolated polypeptide comprising:
- (i) amino acids 17-125 of human HDM2 as set forth in SEQ ID NO:
- 1;
- (ii) amino acids 17-125 of human HDM2 as set forth in SEQ ID NO:
- 1 comprising an F55Y mutation;
- (iii) amino acids 17-125 of human HDM2 as set forth in SEQ ID NO:
- 1 comprising a Y76H mutation;
- or
- (iv) amino acids 17-125 of human HDM2 as set forth in SEQ ID NO:
- 1 comprising an F55Y/Y76H double mutation;
- complexed with a compound
7 more elements
Dependencies are inferred from the claim text.